Hematopoietic defects in response to reduced Arhgap21
Sign Up to like & getrecommendations! Published in 2018 at "Stem cell research"
DOI: 10.1016/j.scr.2017.11.014
Abstract: Arhgap21 is a member of the Rho GTPase activating protein (RhoGAP) family, which function as negative regulators of Rho GTPases. Arhgap21 has been implicated in adhesion and migration of cancer cells. However, the role of… read more here.
Keywords: arhgap21 mice; reduced arhgap21; defects response; hematopoietic defects ... See more keywords
RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007804
Abstract: Key Points • Coexistence of the Srsf2 P95H mutation and Runx1 deficiency recapitulates the multilineage hematopoietic defects observed in MDS.• RUNX1 deficiency strikingly alters global splicing patterns and synergizes with the Srsf2 P95H mutation to… read more here.
Keywords: runx1 deficiency; multilineage hematopoietic; hematopoietic defects; mds runx1 ... See more keywords