PEAR1 is a potential regulator of early hematopoiesis of human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30924
Abstract: Hemogenic endothelial (HE) cells are specialized endothelial cells to give rise to hematopoietic stem/progenitor cells during hematopoietic development. The underlying mechanisms that regulate endothelial‐to‐hematopoietic transition (EHT) of human HE cells are not fully understand. Here,… read more here.
Keywords: human pluripotent; regulator early; hematopoietic development; pear1 cells ... See more keywords
A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2019.228064
Abstract: Hematopoietic development is spatiotemporally tightly regulated by defined cell-intrinsic and extrinsic modifiers. The role of cytokines has been intensively studied in adult hematopoiesis; however, their role in embryonic hematopoietic specification remains largely unexplored. Here, we… read more here.
Keywords: hematopoietic development; early human; human hematopoietic; hematopoietic specification ... See more keywords
Regulation of Ribosome Function by RNA Modifications in Hematopoietic Development and Leukemia: It Is Not Only a Matter of m6A
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DOI: 10.3390/ijms22094755
Abstract: Growth and maturation of hematopoietic stem cells (HSCs) are largely controlled at both transcriptional and post-transcriptional levels. In particular, hematopoietic development requires a tight control of protein synthesis. Furthermore, translational deregulation strongly contributes to hematopoietic… read more here.
Keywords: rna modifications; hematopoietic development; regulation ribosome; m6a ... See more keywords