LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107600
Abstract: Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis. In this study, we identified leucine-rich-repeat-containing… read more here.
Keywords: hematopoiesis; hematopoietic differentiation; beta signaling; hpsc hematopoiesis ... See more keywords
TRANSCRIPTOMIC ANALYSIS OF EARLY HEMATOPOIETIC DEVELOPMENT FROM HUMAN PLURIPOTENT STEM CELLS BY SINGLE-CELL RNA-SEQ IDENTIFIES THE PROMOTING EFFECT OF ARTERIAL ENDOTHELIUM
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.434
Abstract: Human pluripotent stem cells (hPSCs) provide a powerful platform for studying the dynamic molecular network towards hematopoiesis. To date, a comprehensive roadmap at single-cell level for hPSC-derived hematopoietic differentiation has not been established. Here, we… read more here.
Keywords: hematopoietic differentiation; endothelium; cell; single cell ... See more keywords
Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level
Sign Up to like & getrecommendations! Published in 2022 at "BMC Biology"
DOI: 10.1186/s12915-022-01264-9
Abstract: Background Mature blood cells arise from hematopoietic stem cells in the bone marrow by a process of differentiation along one of several different lineage trajectories. This is often represented as a series of discrete steps… read more here.
Keywords: differentiation; expression; variability; hematopoietic differentiation ... See more keywords
Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc18040
Abstract: Background and Objectives Embryonic stem (ES) cells have pluripotent ability to differentiate into multiple tissue lineages. SIRT1 is a class III histone deacetylase which modulates chromatin remodeling, gene silencing, cell survival, metabolism, and development. In… read more here.
Keywords: hematopoietic differentiation; differentiation; differentiation mouse; embryonic stem ... See more keywords
Nucleoredoxin Downregulation Reduces β-Catenin Levels and Shifts Hematopoietic Differentiation towards Myeloid Lineage In Vitro
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.3390/biochem1010003
Abstract: The importance of dissecting signaling pathways governing cell differentiation is based on their relevance not only for understanding basic biological phenomena but also for better comprehending the underlying mechanisms of pathologic alterations such as cancer.… read more here.
Keywords: wnt catenin; differentiation; catenin; hematopoietic differentiation ... See more keywords