Zebrafish models of leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.11.013
Abstract: The zebrafish, Danio rerio, is a well-established, invaluable model system for the study of human cancers. The genetic pathways that drive oncogenesis are highly conserved between zebrafish and humans, and multiple unique attributes of the… read more here.
Keywords: hematopoietic malignancies; model; zebrafish models; models leukemia ... See more keywords
Total marrow irradiation for hematopoietic malignancies using volumetric modulated arc therapy: A review of treatment planning studies☆☆☆
Sign Up to like & getrecommendations! Published in 2019 at "Physics and Imaging in Radiation Oncology"
DOI: 10.1016/j.phro.2019.08.001
Abstract: Total Marrow Irradiation (TMI) has been introduced in the management of hematopoietic malignancies with the aim of reducing toxicities induced by total body irradiation. TMI is one of the most challenging planning and delivery techniques… read more here.
Keywords: irradiation; total marrow; treatment planning; marrow irradiation ... See more keywords
Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25842-7
Abstract: Cancer cells depend on actin cytoskeleton rearrangement to carry out hallmark malignant functions including activation, proliferation, migration and invasiveness. Wiskott–Aldrich Syndrome protein (WASp) is an actin nucleation-promoting factor and is a key regulator of actin… read more here.
Keywords: nucleation promoting; hematopoietic malignancies; actin nucleation; promoting factor ... See more keywords
Stagnation in quality of next-generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of genetic counseling"
DOI: 10.1101/2022.06.14.22276069
Abstract: Importance: Hereditary hematopoietic malignancies (HHMs) are hereditary cancer syndromes that constitute at least 14% of all myeloid malignancies, but genetic assays used to diagnose HHMs have historically been of variable quality. Here, we demonstrate that… read more here.
Keywords: quality; hhm; diagnosis; hematopoietic malignancies ... See more keywords
Non-Coding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-1128
Abstract: Mutations in protein-coding genes are well established as the basis for human cancer, yet it remains elusive how alterations within non-coding genome, a substantial fraction of which contain cis-regulatory elements (CREs), contribute to cancer pathophysiology.… read more here.
Keywords: variants connect; coding variants; hematopoietic malignancies; non coding ... See more keywords
Characterization of Oral Microbiota Following Chemotherapy in Patients With Hematopoietic Malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Integrative Cancer Therapies"
DOI: 10.1177/15347354231159309
Abstract: Oral microbiota may be associated with serious local or systemic medical conditions resulting from chemotherapy. This study was conducted to evaluate the changes in the oral microbiota following the initiation of chemotherapy in patients with… read more here.
Keywords: hematopoietic malignancies; chemotherapy patients; oral microbiota; patients hematopoietic ... See more keywords
RNA modifications in hematopoietic malignancies: A new research frontier.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2019004263
Abstract: Both protein-coding and noncoding RNAs can be decorated with a wealth of chemical modifications and such modifications coordinately orchestrate gene expression during normal hematopoietic differentiation and development. However, aberrant expression and/or dysfunction of the relevant… read more here.
Keywords: modifications hematopoietic; rna modifications; hematopoietic malignancies; malignancies new ... See more keywords
Dysregulation of the TET family of epigenetic regulators in hematopoietic malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019791475
Abstract: DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation and cancer. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter… read more here.
Keywords: epigenetic regulators; tet family; family epigenetic; dysregulation tet ... See more keywords
Targeting cholesterol homeostasis in hematopoietic malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2021012788
Abstract: Cholesterol is a vital lipid for cellular functions. It is necessary for membrane biogenesis, cell proliferation and differentiation. In addition to maintaining cell integrity and permeability, increasing evidence indicates a strict link between cholesterol homeostasis,… read more here.
Keywords: homeostasis hematopoietic; cholesterol homeostasis; cholesterol; targeting cholesterol ... See more keywords
Monitoring plasma nucleosome concentrations to measure disease response and progression in dogs with hematopoietic malignancies
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281796
Abstract: Background Hematopoietic malignancies are extremely common in pet dogs and represent nearly 30% of the malignancies diagnosed in this population each year. Clinicians commonly use existing tools such as physical exam findings, radiographs, ultrasound and… read more here.
Keywords: disease; progression; hematopoietic malignancies; nucleosome concentrations ... See more keywords
Prioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1084736
Abstract: Germline predisposition to hematopoietic malignancies is more common than previously appreciated, with several clinical guidelines advocating for cancer risk testing in an expanding pool of patients. As molecular profiling of tumor cells becomes a standard… read more here.
Keywords: testing based; germline testing; hematopoietic malignancies; prioritization patients ... See more keywords