The emergence of the calvarial hematopoietic niche in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13120
Abstract: The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to the underlying meninges. The presence of ossified vascular channels traversing the inner skull of cortex provides a passageway… read more here.
Keywords: disease; niche; emergence calvarial; calvarial hematopoietic ... See more keywords
Neutrophils as regulators of the hematopoietic niche.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2018-10-844571
Abstract: The niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation… read more here.
Keywords: immune; regulators hematopoietic; neutrophils regulators; hematopoietic niche ... See more keywords
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019031948
Abstract: The bioactive lipid mediator sphingosine 1-phosphate (S1P) was recently assigned critical roles in platelet biology: whereas S1P1 receptor-mediated S1P gradient sensing was reported to be essential for directing proplatelet extensions from megakaryocytes (MKs) toward bone… read more here.
Keywords: platelet production; deletion; hematopoietic niche; biology ... See more keywords
Functionalized 3D scaffolds for engineering the hematopoietic niche
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.968086
Abstract: Hematopoietic stem cells (HSCs) reside in a subzone of the bone marrow (BM) defined as the hematopoietic niche where, via the interplay of differentiation and self-renewal, they can give rise to immune and blood cells.… read more here.
Keywords: engineering hematopoietic; functionalized scaffolds; niche; hematopoietic niche ... See more keywords
Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.912060
Abstract: Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in… read more here.
Keywords: regulator hematopoietic; vascular niche; niche; hematopoietic vascular ... See more keywords