Heparin‐induced thrombocytopenia associated with collection of hematopoietic progenitor cells by apheresis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21757
Abstract: Heparin‐induced thrombocytopenia (HIT) can occur following exposure to heparin and is characterized by thrombocytopenia with increased risk for thrombosis. This condition is mediated by formation of immunoglobulin G antibodies against platelet factor 4/heparin complexes that… read more here.
Keywords: heparin; hematopoietic progenitor; induced thrombocytopenia; heparin induced ... See more keywords
Chronic stress is associated with reduced circulating hematopoietic progenitor cell number: A maternal caregiving model
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.09.009
Abstract: BACKGROUND Chronic psychological stress is a risk factor for cardiovascular disease and mortality. Circulating hematopoietic progenitor cells (CPCs) maintain vascular homeostasis, correlate with preclinical atherosclerosis, and prospectively predict cardiovascular events. We hypothesize that (1) chronic… read more here.
Keywords: negative interactions; cpcs; hematopoietic progenitor; number ... See more keywords
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00473
Abstract: Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted in an increase in… read more here.
Keywords: spiro azaindoline; progenitor kinase; hpk1; kinase ... See more keywords
DPP4+ exosomes in AML patients’ plasma suppress proliferation of hematopoietic progenitor cells
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-01047-7
Abstract: Mechanisms by which acute myeloid leukemia (AML) interferes with normal hematopoiesis are under intense investigation. Emerging evidence suggests that exosomes produced by leukemia blasts suppress hematopoiesis. Exosomes isolated from AML patients’ plasma at diagnosis significantly… read more here.
Keywords: patients plasma; hematopoiesis; progenitor cells; aml patients ... See more keywords
Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of radiation biology"
DOI: 10.1080/09553002.2020.1807643
Abstract: Purpose: The assessment of biological consequences of long-term low dose-rate radiation on wild animals after Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident is important. Many studies on wild animals have showed both negligible and significant… read more here.
Keywords: colony forming; air; hematopoietic progenitor; mice ... See more keywords
BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2018.0020
Abstract: Cellular therapies are emerging as a novel treatment strategy for diabetes. Thus, the induction of endogenous islet regeneration in situ represents a feasible goal for diabetes therapy. Umbilical cord blood-derived hematopoietic progenitor cells (HPCs), isolated… read more here.
Keywords: expansion; bms 493; hematopoietic progenitor; islet regeneration ... See more keywords
Metabolic control of cell fate bifurcations in a hematopoietic progenitor population
Sign Up to like & getrecommendations! Published in 2018 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12040
Abstract: Growth signals drive hematopoietic progenitor cells to proliferate and branch into divergent cell fates, but how unequal outcomes arise from a common progenitor is not fully understood. We used steady‐state analysis of in vivo hematopoiesis… read more here.
Keywords: hematopoietic progenitor; cell fate; progenitor; cell ... See more keywords
Flashback 1997: collection of hematopoietic progenitor cells by peripheral blood apheresis after stimulation with granulocyte–colony‐stimulating factor
Sign Up to like & getrecommendations! Published in 2017 at "Transfusion"
DOI: 10.1111/trf.14332
Abstract: Two videos were produced in 1997 as educational material for patients and blood donor volunteers who considered undergoing hematopoietic progenitor cell (HPC) collection by peripheral blood apheresis. The 6-minute videos featured the discussion between a… read more here.
Keywords: hematopoietic progenitor; peripheral blood; blood; collection ... See more keywords
Abstract 693: A novel multi-subset dendritic cell vaccine derived from hematopoietic progenitor cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-693
Abstract: Owing to their molecular features, tissue localization and antigen processing and presentation capacity, dendritic cells (DCs) induce and regulate T cell immunity including licensing T cells to kill target cells. However, tumors often suppress DC… read more here.
Keywords: cell; hematopoietic progenitor; novel multi; progenitor cells ... See more keywords
FGF23 from erythroblasts promotes hematopoietic progenitor mobilization.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020007172
Abstract: Fibroblast growth factor-23 (FGF23) hormone is produced by bone-embedded osteocytes and regulates phosphate homeostasis in kidneys. We found that granulocyte colony-stimulating factor (G-CSF) administration in mice induced a rapid and tremendous increase in FGF23 mRNA… read more here.
Keywords: fgf23; erythroblasts promotes; hematopoietic progenitor; mobilization ... See more keywords
Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0170470
Abstract: Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations… read more here.
Keywords: progenitor cells; apoptosis; increased apoptosis; knockdown hspa9 ... See more keywords