Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Small methods"
DOI: 10.1002/smtd.202201300
Abstract: The sympathetic nervous system (SNS) of the bone marrow regulates the regeneration and mobilization of hematopoietic stem cells. Chemotherapy can damage bone marrow SNS, which impairs hematopoietic regeneration and aggravates hematologic toxicities. This leads to… read more here.
Keywords: bone marrow; marrow; hematopoietic regeneration; chemotherapy ... See more keywords
CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.04.023
Abstract: Summary Hematopoietic stem and progenitor cells (HSPCs) depend on regulatory cytokines from the marrow microenvironment. From an unbiased cytokine screen of murine marrow supernatants, we identified C-C motif chemokine ligand 5 (CCL5) as an endothelial… read more here.
Keywords: hematopoietic regeneration; regeneration; human hematopoietic; ccr5 ... See more keywords
Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4251
Abstract: The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known… read more here.
Keywords: hematopoietic regeneration; recovery; dkk1; regeneration ... See more keywords
Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow
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DOI: 10.1038/nm.4448
Abstract: Endothelial cells are a critical component of the bone marrow (BM) stromal network, which maintains and regulates hematopoietic cells. Vascular regeneration precedes, and is necessary for, successful hematopoietic stem cell (HSC) transplantation, the only cure… read more here.
Keywords: hematopoietic regeneration; regeneration; granulocyte; hematopoietic cells ... See more keywords
Bone Marrow Adipocyte-Derived PAI-1 As a Negative Regulator of Hematopoietic Regeneration
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DOI: 10.1182/blood-2019-125672
Abstract: Introduction: Bone marrow adipocytes (BMAs) reportedly act as negative regulators of hematopoietic regeneration. This can be observed in obese or elderly patients, both of whom exhibit BMA-rich microenvironment with poor hematopoietic regeneration. Though this relationship… read more here.
Keywords: hematopoietic regeneration; regeneration; hsct; mice ... See more keywords