Potential Risks to Stable Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Children With Cerebral X-linked Adrenoleukodystrophy
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Cardiology"
DOI: 10.1001/jamanetworkopen.2018.0769
Abstract: Key Points Question What are the risks to stable neurocognitive outcome after allogeneic hematopoietic stem cell transplantation for childhood cerebral X-linked adrenoleukodystrophy? Findings This single-center case series involving 36 boys with cerebral X-linked adrenoleukodystrophy found… read more here.
Keywords: linked adrenoleukodystrophy; cell transplantation; cerebral linked; stem cell ... See more keywords
Hematopoietic (stem) cell development—how divergent are the roads taken?
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12879
Abstract: This article corrects: Hematopoietic (stem) cell development—how divergent are the roads taken? Volume 590, Issue 22, 3975–3986. Article first published online: 1 September 2016. DOI of original article: https://doi.org/10. 1002/1873-3468.12372. Funding from European Research Council… read more here.
Keywords: roads taken; cell development; stem cell; development divergent ... See more keywords
RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code
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DOI: 10.1002/1873-3468.15014
Abstract: Hematopoietic system aging is characterized by both hematopoietic stem cell (HSC) and niche degeneration resulting in myeloid lineage‐biased differentiation, reduced B cell and T cell lymphopoiesis, increased HSC mobilization, and fat deposition in the bone… read more here.
Keywords: modifications shape; hematopoietic stem; stem cell; cell ... See more keywords
Neurotoxicity after hematopoietic stem cell transplant in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51045
Abstract: Accelerated brain volume loss has been noted following immunoablative autologous hematopoietic stem cell transplantation (IAHSCT) for multiple sclerosis. As with other MS treatments, this is often interpreted as ‘pseudoatrophy’, related to reduced inflammation. Treatment‐related neurotoxicity… read more here.
Keywords: stem cell; cell; multiple sclerosis; hematopoietic stem ... See more keywords
Neurodegenerative disease after hematopoietic stem cell transplantation in metachromatic leukodystrophy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51796
Abstract: OBJECTIVE Metachromatic leukodystrophy is a lysosomal storage disease caused by deficient arylsulfatase A. It is characterized by progressive demyelination and thus mainly affects the white matter. Hematopoietic stem cell transplantation may stabilize and improve white… read more here.
Keywords: matter; stem cell; metachromatic leukodystrophy; transplantation ... See more keywords
Living Biomaterials to Engineer Hematopoietic Stem Cell Niches
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200964
Abstract: Living biointerfaces are a new class of biomaterials combining living cells and polymeric matrices that can act as biologically active and instructive materials that host and provide signals to surrounding cells. Here, living biomaterials based… read more here.
Keywords: biomaterials engineer; cell; living biomaterials; hematopoietic stem ... See more keywords
Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia—A prospective international multicenter trial on behalf of the BFM‐SG and the EBMT‐PDWP
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25511
Abstract: Severe infections (SI) significantly impact on non‐relapse mortality after hematopoietic stem cell transplantation (HSCT). We assessed 432 children and adolescents with acute lymphoblastic leukemia (ALL) after total body irradiation based myeloablative HSCT within the multicenter… read more here.
Keywords: cell transplantation; lymphoblastic leukemia; stem cell; transplantation ... See more keywords
A CRISPR view of hematopoietic stem cells: Moving innovative bioengineering into the clinic
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26588
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas genome engineering has emerged as a powerful tool to modify precise genomic sequences with unparalleled accuracy and efficiency. Major advances in CRISPR technologies over the last 5 years have… read more here.
Keywords: crispr; view hematopoietic; hematopoietic stem; stem cells ... See more keywords
Assessment of donor cell engraftment after hematopoietic stem cell transplantation for sickle cell disease: A review of current and future methods
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26599
Abstract: Hematopoietic stem cell transplantation (HSCT) is the only established curative treatment for sickle cell disease (SCD), a debilitating red blood cell (RBC) disorder with significant prevalence worldwide. Accurate assessment of RBC engraftment following HSCT is… read more here.
Keywords: cell; stem cell; cell transplantation; hematopoietic stem ... See more keywords
Assessing acute toxicity profiles of HLA‐identical hematopoietic stem cell transplantation in pediatric patients with sickle cell anemia: A comprehensive analysis on behalf of the SFGM‐TC
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Hematology"
DOI: 10.1002/ajh.27486
Abstract: While emerging therapies such as gene therapy are being explored, allogenic hematopoietic stem cell transplantation (HSCT) remains the most established curative treatment for sickle cell anemia (SCA). Yet its application is limited by toxicity risks,… read more here.
Keywords: cell transplantation; hematopoietic stem; stem cell; cell ... See more keywords
Efficacy and Safety of Hetrombopag Versus Thrombopoietin in Promoting Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective, Multicenter, Randomized Controlled Clinical Trial
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Hematology"
DOI: 10.1002/ajh.27746
Abstract: Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is pivotal for hematological malignancies but faces challenges in delayed platelet engraftment, poor graft function (PGF), and bleeding risks. Hetrombopag, a thrombopoietin receptor agonist, was evaluated to enhance platelet… read more here.
Keywords: hetrombopag; platelet engraftment; hematopoietic stem; platelet ... See more keywords