Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis.
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DOI: 10.1016/j.cmet.2020.11.019
Abstract: Regenerative capacity is frequently impaired in aged organs. Stress to aged organs often causes scar formation (fibrosis) at the expense of regeneration. It remains to be defined how hematopoietic and vascular cells contribute to aging-induced… read more here.
Keywords: fibrosis; regeneration; vascular niche; hematopoietic vascular ... See more keywords
Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.912060
Abstract: Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in… read more here.
Keywords: regulator hematopoietic; vascular niche; niche; hematopoietic vascular ... See more keywords