LincRNA-p21 promotes p21-mediated cell cycle arrest in benzene-induced hematotoxicity by sponging miRNA-17-5p.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.118706
Abstract: Benzene is widely employed in manufacturing and causes hematotoxic effects and leukemia in humans. A long intergenic noncoding RNA (lincRNA)-microRNA (miRNA)-mRNA coexpression and competing endogenous RNA (ceRNA) regulatory network was constructed by bioinformatics analysis based… read more here.
Keywords: benzene induced; p21; cell; hematotoxicity ... See more keywords
Polycyclic aromatic hydrocarbons exposure and hematotoxicity in occupational population: A two-year follow-up study.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114622
Abstract: BACKGROUND Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational pollutants. To date, the effect and mechanism by which PAHs exposure impaired hematopoietic system remains unclear. METHODS We examined the capability of PAHs to disrupt… read more here.
Keywords: hematotoxicity; hydrocarbons exposure; study; aromatic hydrocarbons ... See more keywords
Structural Analysis and Prediction of Hematotoxicity Using Deep Learning Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01088
Abstract: Hematotoxicity has been becoming a serious but overlooked toxicity in drug discovery. However, only a few in silico models have been reported for the prediction of hematotoxicity. In this study, we constructed a high-quality dataset… read more here.
Keywords: hematotoxicity; prediction hematotoxicity; prediction; analysis ... See more keywords
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells
Sign Up to like & getrecommendations! Published in 2022 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-022-00556-8
Abstract: Background Hydroquinone (HQ) is a phenolic metabolite of benzene with a potential risk for hematological disorders and hematotoxicity in humans. In the present study, an integrative analysis of microRNA (miRNA) and mRNA expressions was performed… read more here.
Keywords: leukemia; potential pathways; hematotoxicity; associated benzene ... See more keywords
Inflammatory abrasion of hematopoietic stem cells: a candidate clue for the post-CAR-T hematotoxicity?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1141779
Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable effects in treating various hematological malignancies. However, hematotoxicity, specifically neutropenia, thrombocytopenia, and anemia, poses a serious threat to patient prognosis and remains a less focused adverse… read more here.
Keywords: hematotoxicity; car therapy; car; hematopoietic stem ... See more keywords
Ameliorative Effects of Bovine Lactoferrin on Benzene-Induced Hematotoxicity in Albino Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.907580
Abstract: Benzene (Bz) is one of the major products of the petrochemical industry globally, which induces aplastic anemia and leukemia in humans and animals. This study aimed to investigate the modulatory effects of bovine lactoferrin (bLf)… read more here.
Keywords: hematotoxicity; hematotoxicity albino; induced hematotoxicity; effects bovine ... See more keywords
Assessment of γ-H2AX and 53BP1 Foci in Peripheral Blood Lymphocytes to Predict Subclinical Hematotoxicity and Response in Somatostatin Receptor-Targeted Radionuclide Therapy for Advanced Gastroenteropancreatic Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13071516
Abstract: Simple Summary Assessment of the radiation-induced alterations in peripheral blood lymphocytes is a validated strategy for biological dosimetry and assessment of individual radiosensitivity. However, its clinical significance as a liquid biopsy for predicting hematotoxicity and… read more here.
Keywords: h2ax 53bp1; response; hematotoxicity; peripheral blood ... See more keywords
Association between Promoter Methylation of Gene ERCC3 and Benzene Hematotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph14080921
Abstract: Benzene is a primary industrial chemical and a ubiquitous environmental pollutant. ERCC3 is a key player in nucleotide excision repair. Recent studies suggested that site-specific methylation is a possible mechanism of the transcriptional dysregulation by… read more here.
Keywords: methylation; hematotoxicity; promoter methylation; benzene ... See more keywords