The Cys‐Pro motifs in the intrinsically disordered regions of the transcription factor BACH1 mediate distinct and overlapping functions upon heme binding
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DOI: 10.1002/1873-3468.14338
Abstract: The function of the transcription factor BACH1 is regulated by heme binding to multiple Cys‐Pro (CP) motifs within its intrinsically disordered regions. Here, biochemical analyses were conducted to reveal the individual functional roles of the… read more here.
Keywords: cys pro; heme; heme binding; factor bach1 ... See more keywords
Mycobacterium tuberculosis low molecular weight T‐cell antigen Mtb8.4 has heme‐binding and fiber‐forming properties
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14446
Abstract: Mtb8.4, a secretory T‐cell antigen of Mycobacterium tuberculosis, is important for providing an antigen‐specific immune response. In this study, we showed Mtb8.4 to have both heme‐binding and fibril‐forming properties, using experimental and in silico methods.… read more here.
Keywords: heme; heme binding; mtb8 heme; mtb8 ... See more keywords
Cryo‐EM Analysis of a Tri‐Heme Cytochrome‐Associated RC‐LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae
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DOI: 10.1002/advs.202413456
Abstract: The reaction center‐light harvesting 1 (RC‐LH1) complex converts solar energy into electrical energy, driving the initiation of photosynthesis. The authors present a cryo‐electron microscopy structure of the RC‐LH1 isolated from a marine photoheterotrophic bacterium Dinoroseobacter… read more here.
Keywords: marine photoheterotrophic; heme; lh1; photoheterotrophic bacterium ... See more keywords
The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso‐occlusive crises
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24750
Abstract: Sickle Cell Disease (SCD) is a painful, lifelong hemoglobinopathy inherited as a missense point mutation in the hemoglobin (Hb) beta‐globin gene. This disease has significant impact on quality of life and mortality, thus a substantial… read more here.
Keywords: occlusive crises; heme; vaso occlusive; disease ... See more keywords
Improved production of heme using metabolically engineered Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28194
Abstract: Heme has recently attracted much attention due to its promising applications in the food and healthcare industries. However, the current titers and productivities of heme produced by recombinant microorganisms are not high enough for a… read more here.
Keywords: heme; production heme; escherichia coli; engineered escherichia ... See more keywords
A Tough Nut to Crack: Intracellular Detection and Quantification of Heme in Malaria Parasites by a Genetically Encoded Protein Sensor
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700274
Abstract: How free is heme? A fluorescent sensor has been used by Niles and co-workers to detect heme in P. falciparum. ECFP and EYFP were attached to its termini to give a FRET signal that was quenched… read more here.
Keywords: sensor; heme; intracellular detection; crack intracellular ... See more keywords
A Thermostable Heme Protein Fold Adapted for Stereoselective C−H Bond Hydroxylation Using Peroxygenase Activity
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400737
Abstract: Thermostable protein folds of natural and synthetic origin are highly sought‐after templates for biocatalyst generation due to their enhanced stability to elevated temperatures which overcomes one of the major limitations of applying enzymes for synthesis.… read more here.
Keywords: protein fold; protein; stereoselective bond; heme ... See more keywords
Mechanistic Investigation of Biocatalytic Heme Carbenoid Si−H Insertions
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DOI: 10.1002/cctc.201801755
Abstract: Recent studies reported the development of biocatalytic heme carbenoid Si−H insertions for the selective formation of carbon‐silicon bonds, but many mechanistic questions remain unaddressed. To this end, a DFT mechanistic investigation was performed which reveals… read more here.
Keywords: heme; biocatalytic heme; carbenoid insertions; heme carbenoid ... See more keywords
Fluorene‐Chloroquine Hybrids: Synthesis, in vitro Antiplasmodial Activity, and Inhibition of Heme Detoxification Machinery of Plasmodium falciparum
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DOI: 10.1002/cmdc.202200414
Abstract: Fluorene‐chloroquine hybrids have been identified as a new promising class of antiplasmodial agents. The most active compound 9 d exhibited good in vitro antiplasmodial activity against a chloroquine‐sensitive NF54 strain of the human malaria parasite Plasmodium falciparum… read more here.
Keywords: inhibition; heme; fluorene chloroquine; chloroquine hybrids ... See more keywords
General Preparation of Heme Protein Functional Fe3O4@Au-Nps Magnetic Nanocomposite for Sensitive Detection of Hydrogen Peroxide
Sign Up to like & getrecommendations! Published in 2017 at "Electroanalysis"
DOI: 10.1002/elan.201600457
Abstract: Stable magnetic nanocomposite of gold nanoparticles (Au-NPs) decorating Fe3O4 core was successfully synthesized by the linker of Boc-L-cysteine. Transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDX) and cyclic voltammograms (CV) were performed to characterize… read more here.
Keywords: hydrogen peroxide; fe3o4 nps; magnetic nanocomposite; heme ... See more keywords
Spectroscopic evidence of the effect of hydrogen peroxide excess on the coproheme decarboxylase from actinobacterial Corynebacterium diphtheriae
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Raman Spectroscopy"
DOI: 10.1002/jrs.6326
Abstract: Abstract The actinobacterial coproheme decarboxylase from Corynebacterium diphtheriae catalyzes the final reaction to generate heme b via the “coproporphyrin‐dependent” heme biosynthesis pathway in the presence of hydrogen peroxide. The enzyme has a high reactivity toward… read more here.
Keywords: hydrogen peroxide; coproheme decarboxylase; effect; heme ... See more keywords