Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis (Adv. Sci. 6/2023)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205580
Abstract: By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity. Here a strategy for improving intracellular… read more here.
Keywords: biosynthesis; fine tuned; heme biosynthesis; whole cell ... See more keywords
Oxadiazon Derivatives Elicit Potent Intracellular Growth Inhibition against Toxoplasma gondii by Disrupting Heme Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00020
Abstract: Infections of Toxoplasma gondii can cause severe and sometimes fatal diseases in immunocompromised individuals. The de novo heme biosynthesis pathway is required for intracellular growth and pathogenesis, making it an appealing therapeutic target. We synthesized… read more here.
Keywords: inhibition; gondii; intracellular growth; heme biosynthesis ... See more keywords
Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06883-x
Abstract: In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function. While lncRNAs modulate diverse physiological and pathological cellular… read more here.
Keywords: erythrocyte development; mechanism; heme; heme biosynthesis ... See more keywords
Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05415-4
Abstract: Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent… read more here.
Keywords: study; sleep apnea; heme biosynthesis; iron heme ... See more keywords
Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92409
Abstract: The increased heme biosynthesis long observed in leukemia was previously of unknown significance. Heme, synthesized from porphyrin precursors, plays a central role in oxygen metabolism and mitochondrial function, yet little is known about its role… read more here.
Keywords: heme; heme biosynthesis; leukemogenesis; mycn ... See more keywords
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.214320
Abstract: Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by the proposed role of ABCB7 in exporting a… read more here.
Keywords: heme biosynthesis; ferrochelatase; abcb7 abcb10; iron ... See more keywords
Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.907442
Abstract: Objective The intraoperative visualization of adult-type diffuse gliomas with 5-aminolevulinic acid (5-ALA) induced fluorescence is widely used in the neurosurgical field. While visible 5-ALA induced fluorescence is found in the majority of high-grade gliomas, most… read more here.
Keywords: protein expression; heme biosynthesis; expression; gliomas ... See more keywords
The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.928355
Abstract: Background The prognosis of diffusely infiltrating glioma patients is dismal but varies greatly between individuals. While characterization of gliomas primarily relied on histopathological features, molecular markers increasingly gained importance and play a key role in… read more here.
Keywords: biosynthesis; biosynthesis mrna; heme biosynthesis; molecular markers ... See more keywords
Highly Reduced Plastid Genomes of the Non-photosynthetic Dictyochophyceans Pteridomonas spp. (Ochrophyta, SAR) Are Retained for tRNA-Glu-Based Organellar Heme Biosynthesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.602455
Abstract: Organisms that have lost their photosynthetic capabilities are present in a variety of eukaryotic lineages, such as plants and disparate algal groups. Most of such non-photosynthetic eukaryotes still carry plastids, as these organelles retain essential… read more here.
Keywords: non photosynthetic; heme biosynthesis; plastid; plastid genomes ... See more keywords
Cellular Zinc Deficiency Impairs Heme Biosynthesis in Developing Erythroid Progenitors
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DOI: 10.3390/nu15020281
Abstract: Anemia is the most prevalent nutrition-related disorder worldwide. Zinc is an essential trace element for various biological processes in the body, and zinc deficiency has been associated with anemia in humans. However, the molecular mechanisms… read more here.
Keywords: zinc deficiency; deficiency; zinc; heme biosynthesis ... See more keywords
Erythropoietin signaling regulates heme biosynthesis
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.24767
Abstract: Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to… read more here.
Keywords: heme biosynthesis; signaling regulates; erythropoietin signaling; regulates heme ... See more keywords