Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
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DOI: 10.1038/ncomms15320
Abstract: The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here… read more here.
Keywords: biosynthetic intermediates; heme biosynthetic; intermediates contributes; accumulation heme ... See more keywords
Circadian Genes Expression Patterns in Disorders Due to Enzyme Deficiencies in the Heme Biosynthetic Pathway
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DOI: 10.3390/biomedicines10123198
Abstract: Heme is a member of the porphyrins family of cyclic tetrapyrroles and influences various cell processes and signalling pathways. Enzyme deficiencies in the heme biosynthetic pathway provoke rare human inherited metabolic diseases called porphyrias. Protein… read more here.
Keywords: enzyme deficiencies; heme biosynthetic; expression; circadian genes ... See more keywords