An Engineered Glutamate in Biosynthetic Models of Heme-Copper Oxidases Drives Complete Product Selectivity by Tuning the Hydrogen-Bonding Network.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00852
Abstract: Efficiently carrying out the oxygen reduction reaction (ORR) is critical for many applications in biology and chemistry, such as bioenergetics and fuel cells, respectively. In biology, this reaction is carried out by large, transmembrane oxidases… read more here.
Keywords: biochemistry; hydrogen bonding; copper oxidases; heme copper ... See more keywords
Activation of O2 and NO in heme-copper oxidases - mechanistic insights from computational modelling.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Society reviews"
DOI: 10.1039/d0cs00877j
Abstract: Heme-copper oxidases are transmembrane enzymes involved in aerobic and anaerobic respiration. The largest subgroup contains the cytochrome c oxidases (CcO), which reduce molecular oxygen to water. A significant part of the free energy released in… read more here.
Keywords: reduction; copper oxidases; energy; chemistry ... See more keywords
A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2001572117
Abstract: Significance We present a comprehensive investigation of mitochondrial DNA-encoded variants of cytochrome c oxidase (CcO) that harbor mutations within their core catalytic subunit I, designed to interrogate the presently disputed functions of the three putative… read more here.
Keywords: cco; mechanism; type heme; heme copper ... See more keywords
Complex Interplay of Heme-Copper Oxidases with Nitrite and Nitric Oxide
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020979
Abstract: Nitrite and nitric oxide (NO), two active and critical nitrogen oxides linking nitrate to dinitrogen gas in the broad nitrogen biogeochemical cycle, are capable of interacting with redox-sensitive proteins. The interactions of both with heme-copper… read more here.
Keywords: copper; nitrite nitric; nitric oxide; heme copper ... See more keywords