The Interplay between Molten Globules and Heme Disassociation Defines Human Hemoglobin Disassembly.
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DOI: 10.1016/j.bpj.2020.01.031
Abstract: Hemoglobin functions as a tetrameric oxygen transport protein, with each subunit containing a heme cofactor. Its denaturation, either in vivo or in vitro, involves autoxidation to methemoglobin, followed by cofactor loss and globin unfolding. We have proposed… read more here.
Keywords: heme disassociation; hemoglobin; molten globules; globules heme ... See more keywords