Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.07.006
Abstract: Bilirubin is one of the most frequently measured metabolites in medicine, yet its physiologic roles remain unclear. Bilirubin can act as an antioxidant in vitro, but whether its redox activity is physiologically relevant is unclear because… read more here.
Keywords: links heme; bilirubin links; heme metabolism; redox activity ... See more keywords
Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Bone and Mineral Research"
DOI: 10.1093/jbmr/zjaf040
Abstract: Abstract Bone undergoes life-long remodeling, in which disorders of bone remodeling could occur in many pathological conditions including osteoporosis. Understanding the cellular metabolism of osteoclasts (OCs) is key to developing new treatments for osteoporosis, a… read more here.
Keywords: metabolism mediates; osteoclastogenesis; heme; metabolism ... See more keywords
Heme metabolism and HO‐1 in the pathogenesis and potential intervention of endometriosis
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13855
Abstract: Endometriosis (EM) is one of the diseases related to retrograded menstruation and hemoglobin. Heme, released from hemoglobin, is degraded by heme oxygenase‐1 (HO‐1). In EM lesions, heme metabolites regulate processes such as inflammation, redox balance,… read more here.
Keywords: heme; heme metabolism; endometriosis; metabolism pathogenesis ... See more keywords
Active Heme Metabolism Suppresses Macrophage Phagocytosis via the TLR4/Type I IFN Signaling/CD36 in Uterine Endometrial Cancer
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DOI: 10.1111/aji.13916
Abstract: Uterine endometrial cancer (UEC) is a common gynecological estrogen‐dependent carcinoma, usually accompanied by intermenstrual bleeding. Active heme metabolism frequently plays an increasingly important role in many diseases, especially in cancers. Tumor‐associated macrophages (TAMs) are the… read more here.
Keywords: endometrial cancer; uterine endometrial; heme metabolism; active heme ... See more keywords
Monocyte–red blood cell crosstalk supports clearance and heme metabolism in sickle cell anemia
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DOI: 10.3389/fimmu.2025.1699306
Abstract: Background Monocytes can interact with erythroid cells and contribute to macrophage pools under anemic stress, thereby supporting the erythropoietic niche. In sickle cell anemia (SCA), extensive hemolysis and ineffective erythropoiesis may expose circulating monocytes to… read more here.
Keywords: cell anemia; cell; heme metabolism; red blood ... See more keywords
Light-Induced Transcription in Zebrafish Targets Mitochondrial Function and Heme Metabolism
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DOI: 10.3390/antiox14101151
Abstract: In fish cells, light exposure elevates levels of reactive oxygen species (ROS) and stress-activated MAP kinase activity and thereby induces gene transcription. However, we lack a complete understanding of the function and evolution of this… read more here.
Keywords: function; heme metabolism; transcription; induced transcription ... See more keywords