Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis
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DOI: 10.1002/advs.202203286
Abstract: Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair… read more here.
Keywords: heme oxygenase; adipose tissue; type diabetes; pbp nps ... See more keywords
Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos
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DOI: 10.1002/bdr2.2087
Abstract: Heme oxygenase 1 or Hmox1 enzyme is involved in catalyzing the first and rate‐limiting step in heme breakdown reactions. Many studies have reported a partial lethality of Hmox1 knockout mice obtained from heterozygous breeding pairs.… read more here.
Keywords: sex ratios; embryonic stages; heme oxygenase; sex ... See more keywords
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D‐QSAR Coupled to Scaffold‐Hopping Analysis
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DOI: 10.1002/cmdc.201800176
Abstract: A 3D quantitative structure–activity relationship (3D‐QSAR) model for predicting the activity of heme oxygenase 1 (HO‐1) inhibitors was constructed with the aim of providing a useful tool for the identification, design, and optimization of novel HO‐1… read more here.
Keywords: scaffold hopping; heme oxygenase; model; oxygenase inhibitors ... See more keywords
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
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DOI: 10.1002/cmdc.202300047
Abstract: In this work, we extend the concept of 5‐fluorouracil/heme oxygenase 1 (5‐FU/HO‐1) inhibitor hybrid as an effective strategy for enhancing 5‐FU‐based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI… read more here.
Keywords: imidazole based; oxygenase inhibitor; mutual prodrugs; heme oxygenase ... See more keywords
The immunosuppression pathway of tumor‐associated macrophages is controlled by heme oxygenase‐1 in glioblastoma patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34270
Abstract: The immunosuppressive tumor microenvironment (TME) in glioblastoma (GBM) is mainly driven by tumor‐associated macrophages (TAMs). We explored whether their sustained iron metabolism and immunosuppressive activity were correlated, and whether blocking the central enzyme of the… read more here.
Keywords: glioblastoma; heme oxygenase; activity; associated macrophages ... See more keywords
Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1462-z
Abstract: Endothelin-1 (ET-1), a potent vasoconstrictor normally active in maintaining vascular tone, may mediate significant pathogenic effects, contributing to several serious diseases when aberrantly expressed or regulated. The present study evaluates the capacity of ET-1 to… read more here.
Keywords: cell viability; vitro vivo; heme oxygenase; expression ... See more keywords
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02187-x
Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood–brain barrier… read more here.
Keywords: blood brain; heme oxygenase; autoimmune neuroinflammation; brain barrier ... See more keywords
The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic brain disease"
DOI: 10.1007/s11011-022-00990-x
Abstract: Sulforaphane (SFN) promotes protective effects in different cell types. Nonetheless, it remains to be clarified by which mechanism SFN exerts benefits in mammalian cells. Mitochondria are a major source of adenosine triphosphate (ATP) and reactive… read more here.
Keywords: sfn; bv2 cells; mitochondrial impairment; heme oxygenase ... See more keywords
Ferulic Acid Improves Cognitive Skills Through the Activation of the Heme Oxygenase System in the Rat
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DOI: 10.1007/s12035-017-0381-1
Abstract: Over the last years, many studies reported on the antioxidant effects of ferulic acid (FA) in preclinical models of dementia through the activation of the heme oxygenase/biliverdin reductase (HO/BVR) system. However, only a few studies… read more here.
Keywords: activation heme; habituated rats; heme oxygenase; ferulic acid ... See more keywords
Expression of heme oxygenase-1 in type II pneumocytes protects against heatstroke-induced lung damage
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DOI: 10.1007/s12192-020-01152-7
Abstract: Heatstroke (HS) is an acute clinical disease characterized by abnormal hyperthermia and multi-organ dysfunction. Heme oxygenase (HO)-1, also called heat shock protein (HSP)32, is induced by hyperthermia and also plays protective roles in many lung… read more here.
Keywords: heat; induced lung; heme oxygenase; damage ... See more keywords
Astragalin reduces lipopolysaccharide-induced acute lung injury in rats via induction of heme oxygenase-1.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of pharmacal research"
DOI: 10.1007/s12272-019-01171-8
Abstract: Astragalin, a bioactive component of medicinal plants such as Rosa agrestis, has anti-inflammatory and antioxidant features. Induction of heme oxygenase (HO)-1 is an effective strategy to reduce excessive generated oxidants during the pathogenesis of acute… read more here.
Keywords: astragalin; heme oxygenase; induction heme; lung injury ... See more keywords