Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.053
Abstract: The Wnt/β-catenin signaling pathway controls cell proliferation and differentiation, and therefore, when this pathway is excessively activated, it causes tumorigenesis. Our chemical suppressor screening in zebrafish embryos identified antifungal azoles including clotrimazole, miconazole, and itraconazole,… read more here.
Keywords: regulated translational; heme regulated; catenin pathway; translational inhibitor ... See more keywords
A protective role of Heme-regulated eIF2α kinase in cadmium-induced liver and kidney injuries.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.07.018
Abstract: A number of studies have reported that cadmium (Cd) can incur liver and kidney injuries. The recruitment and activation of leukocytes have been demonstrated to be involved in Cd-induced biological effects. Ironically, activated leukocytes and… read more here.
Keywords: liver kidney; kidney injuries; heme regulated; hri ... See more keywords
Translational control by heme-regulated elF2α kinase during erythropoiesis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000704
Abstract: Purpose of review HRI is the heme-regulated elF2α kinase that phosphorylates the α-subunit of elF2. Although the role of HRI in inhibiting globin synthesis in erythroid cells is well established, broader roles of HRI in… read more here.
Keywords: heme regulated; erythropoiesis; hri; elf2 kinase ... See more keywords