Fiber-optic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors – A preliminary study for improved Photodynamic Therapy applications
Sign Up to like & getrecommendations! Published in 2018 at "Results in physics"
DOI: 10.1016/j.rinp.2018.01.059
Abstract: Abstract In this work we present first results of a laboratory manufactured filter-fluorometer to study differences in intensity and position of the main peaks of three porphyrins that appear during the Heme-Synthesis. Porphyrins play a… read more here.
Keywords: filter fluorometer; photodynamic therapy; study; heme synthesis ... See more keywords
Zinc and the Zinc Transporter SLC39A10/ZIP10 Are Required for Heme Synthesis in Developing Erythroid Progenitors
Sign Up to like & getrecommendations! Published in 2021 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzab059_021
Abstract: Zinc is an essential nutrient for diverse biological processes in the body. Cellular zinc homeostasis is established through differential expressions of the transmembrane zinc transporter proteins, ZnTs and ZIPs. The aims of the current studies… read more here.
Keywords: zip10; g1e er4; zinc transporter; heme synthesis ... See more keywords
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abn8017
Abstract: Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-induced cardiomyopathy (DIC). Mitochondria-dependent ferroptosis, which is triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the… read more here.
Keywords: heme synthesis; iron; doxorubicin; mitochondrial dna ... See more keywords
New Avenues of Heme Synthesis Regulation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137467
Abstract: During erythropoiesis, there is an enormous demand for the synthesis of the essential cofactor of hemoglobin, heme. Heme is synthesized de novo via an eight enzyme-catalyzed pathway within each developing erythroid cell. A large body… read more here.
Keywords: new avenues; heme synthesis; synthesis; regulation ... See more keywords
Improved Bioproduction of the Nylon 12 Monomer by Combining the Directed Evolution of P450 and Enhancing Heme Synthesis
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041758
Abstract: The nylon 12 (PA12) monomer ω-aminododecanoic acid (ω-AmDDA) could be synthesized from lauric acid (DDA) through multi-enzyme cascade transformation using engineered E. coli, with the P450 catalyzing terminal hydroxylation of DDA as a rate-limiting enzyme.… read more here.
Keywords: heme synthesis; p450; directed evolution; enhancing heme ... See more keywords
5-Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Reports"
DOI: 10.3892/or.2022.8401
Abstract: Iron is an essential nutrient that facilitates cell proliferation and growth, and it can contribute to tumor growth. Although iron chelators have shown great potential in preclinical cancer models, they can cause adverse side-effects. The… read more here.
Keywords: heme synthesis; proliferation; expression; bladder cancer ... See more keywords