Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.
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DOI: 10.1021/acs.chemrestox.8b00353
Abstract: Human cytochrome P450 (P450) family 4 enzymes are involved in the metabolism of fatty acids and the bioactivation of carcinogenic arylamines and toxic natural products, e.g., 4-ipomeanol. These and other drug-metabolizing P450s are redox sensitive,… read more here.
Keywords: heme thiolate; heme; p450 4b1; thiolate ... See more keywords