Cannabinoids prevent the amyloid β‐induced activation of astroglial hemichannels: A neuroprotective mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23080
Abstract: The mechanisms involved in Alzheimer's disease are not completely understood and how astrocytes and their gliotransmission contribute to this neurodegenerative disease remains to be fully elucidated. Previous studies have shown that amyloid‐β peptide (Aβ) induces… read more here.
Keywords: hemichannel activity; mechanism; hemichannel; amyloid induced ... See more keywords
Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1727-5
Abstract: Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and… read more here.
Keywords: hemichannel block; hemichannel; diabetic retinopathy; connexin43 hemichannel ... See more keywords
Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.11.004
Abstract: Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. While most of these disease-linked variants cause loss-of-function due to misfolding or aberrant trafficking, others directly alter channel properties. The mechanistic bases… read more here.
Keywords: enhanced hemichannel; hemichannel; mutant; molecular mechanisms ... See more keywords
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01899
Abstract: The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction. We used EAhy… read more here.
Keywords: high glucose; hemichannel; pro inflammatory; hemichannel activity ... See more keywords
Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021673
Abstract: Previously, we reported a mechanosensitive ion channel, TRPV4, along with functional connexin hemichannels on the basolateral surface of the ocular nonpigmented ciliary epithelium (NPE). In the lens, TRPV4-mediated hemichannel opening is part of a feedback… read more here.
Keywords: stretch; nonpigmented ciliary; ciliary epithelium; atp release ... See more keywords