Cannabinoids prevent the amyloid β‐induced activation of astroglial hemichannels: A neuroprotective mechanism
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DOI: 10.1002/glia.23080
Abstract: The mechanisms involved in Alzheimer's disease are not completely understood and how astrocytes and their gliotransmission contribute to this neurodegenerative disease remains to be fully elucidated. Previous studies have shown that amyloid‐β peptide (Aβ) induces… read more here.
Keywords: hemichannel activity; mechanism; hemichannel; amyloid induced ... See more keywords
The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity
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DOI: 10.1007/s00018-017-2722-7
Abstract: Connexin 43 (Cx43) hemichannels establish local signaling networks via the release of ATP and other molecules, but their excessive opening may result in cell death. Hence, the activity of Cx43-hemichannels ought to be critically controlled.… read more here.
Keywords: binding domain; hemichannel activity; sh3 binding; cx43 ... See more keywords
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function
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DOI: 10.3389/fimmu.2018.01899
Abstract: The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction. We used EAhy… read more here.
Keywords: high glucose; hemichannel; pro inflammatory; hemichannel activity ... See more keywords
Increased Hemichannel Activity Displayed by a Connexin43 Mutation Causing a Familial Connexinopathy Exhibiting Hypotrichosis with Follicular Keratosis and Hyperostosis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032222
Abstract: Mutations in the GJA1 gene that encodes connexin43 (Cx43) cause several rare genetic disorders, including diseases affecting the epidermis. Here, we examined the in vitro functional consequences of a Cx43 mutation, Cx43-G38E, linked to a… read more here.
Keywords: mutation; cx43; cx43 g38e; hemichannel activity ... See more keywords