Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1727-5
Abstract: Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and… read more here.
Keywords: hemichannel block; hemichannel; diabetic retinopathy; connexin43 hemichannel ... See more keywords
Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01352-3
Abstract: Aims The retinal pigment epithelium (RPE) is an important component of the outer blood–retinal barrier (BRB) that separates the choroid from the rest of the retina. Loss of RPE-mediated BRB integrity is a key feature… read more here.
Keywords: connexin43; retinal pigment; hemichannel block; connexin43 hemichannel ... See more keywords