Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-020-00763-y
Abstract: Hypoxic injury results in cell death, tissue damage and activation of inflammatory pathways. This is mediated by pathological Connexin43 (Cx43) hemichannel (HC) opening resulting in osmotic and ionic imbalances as well as cytokine production perpetuating… read more here.
Keywords: hemichannel opening; xentry gap19; hypoxic injury; gap19 ... See more keywords
Cx32 hemichannel opening by cytosolic Ca2+ is inhibited by the R220X mutation that causes Charcot-Marie-Tooth disease
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DOI: 10.1093/hmg/ddx386
Abstract: Mutations of the GJB1 gene encoding connexin 32 (Cx32) cause the X-linked form of Charcot-Marie-Tooth disease (CMTX1), a demyelinating peripheral neuropathy for which there is no cure. A growing body of evidence indicates that ATP… read more here.
Keywords: hemichannel opening; cx32; charcot marie; cytosolic ca2 ... See more keywords
Connexin hemichannels and cell death as measures of bovine COC vitrification success.
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DOI: 10.1530/rep-18-0387
Abstract: Vitrification of immature germinal vesicle-stage oocytes is a promising method in assisted reproduction but is associated with reduced developmental potential and low birth rates. Cumulus-oocyte complexes (COCs) express several connexins that form hexameric hemichannels, which… read more here.
Keywords: hemichannel opening; death; cell death; vitrification ... See more keywords