Fe(III)-Catalyzed Diastereoselective Friedel-Crafts Alkylation-Hemiketalization-Lactonization Cascade for the Synthesis of Polycyclic Bridged 2-Chromanol Lactones.
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DOI: 10.1021/acs.orglett.9b00614
Abstract: An unprecedented Fe(III)-catalyzed Friedel-Crafts alkylation-hemiketalization-lactonization cascade of electron-rich hydroxy arenes and distinctively functionalized unsaturated 4-keto esters is developed for the construction of polycyclic bridged 2-chromanol lactones. Following this simple and facile protocol, a broad range… read more here.
Keywords: crafts alkylation; hemiketalization lactonization; lactonization cascade; alkylation hemiketalization ... See more keywords