Surgical Decompression for Space-Occupying Hemispheric Infarction: A Systematic Review and Individual Patient Meta-analysis of Randomized Clinical Trials.
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DOI: 10.1001/jamaneurol.2020.3745
Abstract: Importance In patients with space-occupying hemispheric infarction, surgical decompression reduces the risk of death and increases the chance of a favorable outcome. Uncertainties, however, still remain about the benefit of this treatment for specific patient… read more here.
Keywords: decompression; hemispheric infarction; surgical decompression; occupying hemispheric ... See more keywords
Safety and Feasibility of YC-6 in Patients With Large Hemispheric Infarction: A Randomized Clinical Trial.
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DOI: 10.1161/jaha.124.039157
Abstract: Background Malignant cerebral edema is a critical cause of poor outcomes in large hemispheric infarction and novel neuroprotective agents are urgently needed. We aimed to assess the safety and preliminarily explored the feasibility of YC‐6… read more here.
Keywords: patients large; large hemispheric; hemispheric infarction; trial ... See more keywords
Abstract 6: HRS8179 in Patients with Cerebral Edema after Large Hemispheric Infarction: A Multicenter, Randomized, Double-blinded, Placebo-controlled, Phase 2 Study
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DOI: 10.1161/str.56.suppl_1.6
Abstract: Background: Large hemispheric infarction (LHI) shows a high risk of cerebral edema and neurological deterioration, even leading to death, but it still has limited treatment options. HRS8179 is a selective sulfonylurea receptor 1 inhibitor, which… read more here.
Keywords: large hemispheric; hemispheric infarction; group; cerebral edema ... See more keywords
Safety and efficacy of low-dose and long-course tirofiban in large hemispheric infarction
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DOI: 10.3389/fneur.2022.987859
Abstract: Background The clinical efficacy and safety of tirofiban in the treatment of large hemispheric infarction (LHI) remain controversial. Methods This study prospectively enrolled patients with acute LHI who were admitted to Putuo Hospital affiliated with… read more here.
Keywords: hemispheric infarction; tirofiban; large hemispheric; group ... See more keywords