3106 – DIRECT INDUCTION OF HEMOGENIC ENDOTHELIUM AND MYELOID CELLS FROM HUMAN IPSCS USING ETV2 MODIFIED RNA
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.118
Abstract: Previously, we demonstrated that overexpressing transcription factors ETV2 and GATA2 is sufficient to induce a pan-myeloid program in human induced pluripotent stem cells (hiPSCs), which proceeds through a hemogenic endothelium (HE) stage (Elcheva et al.,… read more here.
Keywords: myeloid; etv2; presence csf; hemogenic endothelium ... See more keywords
The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming
Sign Up to like & getrecommendations! Published in 2021 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2021.111461
Abstract: The research on neurodegenerative diseases (NeuroDegD) has been traditionally focused on later life stages. There is now an increasing evidence, that they may be programmed during early development. Here, we propose that NeuroDegD are the… read more here.
Keywords: programming; fetal programming; role; hemogenic endothelium ... See more keywords
HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.01.009
Abstract: Summary Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4.… read more here.
Keywords: hoxb4 promotes; formation; hoxb4; hemogenic endothelium ... See more keywords
CD34dim cells identified as pluripotent stem cell‐derived definitive hemogenic endothelium purified using bone morphogenetic protein 4
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13366
Abstract: Hemogenic endothelium (HE) plays a pivotal and inevitable role in haematopoiesis and can generate all blood and endothelial lineage cells in the aorta‐gonad‐mesonephros of mouse embryos. Whether definitive HE can prospectively isolate pure HE from… read more here.
Keywords: pluripotent stem; cd34dim; bone morphogenetic; stem ... See more keywords