Voxelotor (GBT440), a first‐in‐class hemoglobin oxygen‐affinity modulator, has promising and reassuring preclinical and clinical data
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25042
Abstract: Voxelotor, a first-in-class drug, is currently being studied for the treatment of sickle cell disease in the United States and Europe that has received Breakthrough Therapy Designation (BTD) by the Food and Drug Administration (FDA)… read more here.
Keywords: hemoglobin; affinity; voxelotor; first class ... See more keywords
Pre‐anthracycline echocardiogram rarely changes treatment strategy in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25083
Abstract: some clinicians may apply independent criteria to diagnose anemia or may apply tailored criteria based on patient-specific factors. Further work is urgently required to clarify, establish and harmonize hemoglobin thresholds to diagnose anemia. As well… read more here.
Keywords: hemoglobin; rarely changes; pre anthracycline; hemoglobin thresholds ... See more keywords
Induced-orientation of nitrogen monoxide and azide ion vibrations in human hemoglobin in bidistilled water solution under a static magnetic field.
Sign Up to like & getrecommendations! Published in 2017 at "Bioelectromagnetics"
DOI: 10.1002/bem.22056
Abstract: In this study, we report the effects of static magnetic fields (SMFs) at 200 mT on different hemoglobin aqueous solutions, in the absence and in the presence of sucrose and trehalose, studied by FTIR spectroscopic techniques.… read more here.
Keywords: nitrogen monoxide; hemoglobin; water solution; bidistilled water ... See more keywords
Pilot scale production and characterization of next generation high molecular weight and tense quaternary state polymerized human hemoglobin
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28233
Abstract: Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell (RBC) substitute for use in scenarios where blood is not available. While the oxygen (O2) carrying capacity of PolyhHb makes it appealing… read more here.
Keywords: scale; pilot scale; polyhhb; molecular weight ... See more keywords
Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins.
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB life"
DOI: 10.1002/iub.2607
Abstract: Hemoglobin oxidation due to oxidative stress and disease conditions leads to generation of ROS (reactive oxygen species) and membrane attachment of hemoglobin in-vivo, where its redox activity leads to peroxidative damage of membrane lipids and… read more here.
Keywords: hemoglobin; spectrin; heme proteins; spectrin binding ... See more keywords
A comparison of noninvasive methods for early detection of hemorrhage: Inferior vena cava ultrasonography and spectrophotometric hemoglobin levels
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Ultrasound"
DOI: 10.1002/jcu.22709
Abstract: Blood hemoglobin concentration measurements using a spectrophotometric method (SpHb), and inferior vena cava ultrasonography (IVC‐US) are noninvasive methods used to follow‐up hemorrhages. We compared their efficacy using voluntary blood donation as a model of moderate… read more here.
Keywords: hemoglobin; vena cava; inferior vena; cava ultrasonography ... See more keywords
Relationship between hemoglobin levels and vancomycin clearance in patients with sepsis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-019-02661-w
Abstract: PurposeIt is important to accurately estimate accurate vancomycin (VCM) clearance (CLvcm) for appropriate VCM dosing in the treatment of patients with sepsis. However, the pathophysiology of sepsis can make CLvcm prediction less accurate. Clearance of… read more here.
Keywords: sepsis; hemoglobin; sepsis patients; hemoglobin levels ... See more keywords
Efficacy of decitabine as hemoglobin F inducer in HbE/β-thalassemia
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3357-y
Abstract: To study safety, efficacy (hemoglobin and hemoglobin F percentage increment in non-transfusion-dependent patients and decrease in transfusion frequency in transfusion-dependent patients), and determinants of response of decitabine in patients with HbE/β-thalassemia. Thirty patients of HbE/β-thalassemia… read more here.
Keywords: decitabine; transfusion dependent; hbe thalassemia; hemoglobin ... See more keywords
The rare hemoglobin variant Hb Mizuho: report of a Swiss family and literature review
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04458-3
Abstract: Hb Mizuho is a very rare unstable hemoglobin; here, we describe the clinical history of three Swiss family members with Hb Mizuho together with a systematic review of the previously six published cases. The clinical… read more here.
Keywords: hemoglobin; swiss family; report; review ... See more keywords
Prognostic benefit of maintaining the hemoglobin level during the acute phase in patients with severely decompensated acute heart failure
Sign Up to like & getrecommendations! Published in 2017 at "Heart and Vessels"
DOI: 10.1007/s00380-017-1057-5
Abstract: The optimum method of managing anemia during the acute phase of acute heart failure (AHF) remains to be elucidated. The data from 1109 AHF patients were enrolled in present study. The hemoglobin (Hb) levels were… read more here.
Keywords: acute phase; heart; anemia day; hemoglobin ... See more keywords
Prevalence and predictors of blood transfusion after pediatric kidney transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-4017-0
Abstract: BackgroundBlood transfusion after kidney transplant carries a risk of sensitization to the graft as well as blood borne infections.The aim of this study was to describe the prevalence of blood transfusions in pediatric recipients of… read more here.
Keywords: hemoglobin; analysis; transfusion; pre transplant ... See more keywords