Production of functional human fetal hemoglobin in Nicotiana benthamiana for development of hemoglobin-based oxygen carriers.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.06.102
Abstract: Hemoglobin based oxygen carriers (HBOCs) have long been pursued to meet clinical needs by using native hemoglobin (Hb) from human or animal blood, or recombinantly produced Hb, but the development has been impeded by safety… read more here.
Keywords: production; hemoglobin; hemoglobin based; human fetal ... See more keywords
Structural, functional and physiochemical properties of dextran-bovine hemoglobin conjugate as a hemoglobin-based oxygen carrier
Sign Up to like & getrecommendations! Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2017.05.021
Abstract: Abstract As a hemoglobin (Hb)-based oxygen carrier (HBOC), Hb suffers from the disadvantages of short half-life, renal toxicity and vasoactivity. Because dextran is a macromolecule that can be easily derivatized with various chemical moieties, conjugation… read more here.
Keywords: oxygen carrier; hemoglobin; hemoglobin based; dextran ... See more keywords
Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00093
Abstract: The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) has been hampered because of safety concerns in humans. Chemical and/or genetic modifications of the Hb introduce varied structural and conformational constraint on the molecule that resulted… read more here.
Keywords: oxygen; hemoglobin based; biochemical biophysical; comprehensive biochemical ... See more keywords
The Use of Hemoglobin-Based Oxygen Carriers in Ex Vivo Machine Perfusion of Donor Organs for Transplantation.
Sign Up to like & getrecommendations! Published in 2022 at "ASAIO journal"
DOI: 10.1097/mat.0000000000001597
Abstract: There has been significant progress in the development of ex vivo machine perfusion for the nonischemic preservation of donor organs. However, several complications remain, including the logistics of using human blood for graft oxygenation and… read more here.
Keywords: vivo machine; based oxygen; machine perfusion; oxygen ... See more keywords
Ability of a Blue Hemoglobin-Based Liquid as a Novel Technology to Stain Initial Enamel Demineralization: A Proof-of-Concept in vitro Study
Sign Up to like & getrecommendations! Published in 2022 at "Caries Research"
DOI: 10.1159/000528413
Abstract: During orthodontic treatment, enamel demineralization can occur. Its early detection is the basis for efficient preventive measures to arrest or remineralize lesions. In the present study, the application of a novel blue hemoglobin-based liquid (BlueCheck)… read more here.
Keywords: group; enamel demineralization; demineralization; blue hemoglobin ... See more keywords
Hemoglobin-Based Oxygen Carriers: Where Are We Now in 2023?
Sign Up to like & getrecommendations! Published in 2023 at "Medicina"
DOI: 10.3390/medicina59020396
Abstract: The pursuit for blood a substitute has spanned over a century, but a majority of the efforts have been disappointing. As of today, there is no widely accepted product used as an alternative to human… read more here.
Keywords: oxygen carriers; oxygen therapeutics; carriers 2023; based oxygen ... See more keywords