Novel homozygous CD46 variant with C‐isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249838
Abstract: Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that may lead to organ failure. Dysregulation of the complement system can cause aHUS, and various disease‐related variants in the complement regulatory protein CD46 are described.… read more here.
Keywords: atypical hemolytic; expression; uremic syndrome; cd46 ... See more keywords
Blood urea nitrogen to serum creatinine ratio as a prognostic factor in diarrhea-associated hemolytic uremic syndrome: a validation study
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DOI: 10.1007/s00431-017-2999-4
Abstract: AbstractIdentifying those children with complicated forms of diarrhea-associated hemolytic uremic syndrome (D+HUS) on admission can optimize their management. Recently, the blood urea nitrogen to serum creatinine ratio (BCR) at admission has been proposed as a… read more here.
Keywords: uremic syndrome; admission; diarrhea associated; study ... See more keywords
Outbreak of Shiga toxin-producing Escherichia-coli-associated hemolytic uremic syndrome in Istanbul in 2015: outcome and experience with eculizumab
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-4033-0
Abstract: BackgroundThis study aims to identify epidemiological and clinical characteristics of patients and report our experience with eculizumab treatment during an outbreak of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) in Istanbul… read more here.
Keywords: uremic syndrome; toxin producing; hemolytic uremic; experience eculizumab ... See more keywords
C3 levels and acute outcomes in Shiga toxin–related hemolytic uremic syndrome
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DOI: 10.1007/s00467-019-04334-3
Abstract: Background The correlation between complement activation and severity of hemolytic uremic syndrome related to Shiga toxin–producing Escherichia coli (STEC-HUS) has been examined in few studies, with conflicting results. We investigated whether C3 levels on admission… read more here.
Keywords: uremic syndrome; acute outcomes; hemolytic uremic; shiga toxin ... See more keywords
Rasburicase in hemolytic uremic syndrome related to Shiga toxin-producing Escherichia coli: a report of nine cases
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DOI: 10.1007/s00467-020-04528-0
Abstract: Background Hyperuricemia might induce additional renal damage in children with hemolytic uremic syndrome related to Shiga toxin-producing Escherichia coli (STEC-HUS). A few case reports have shown rasburicase to be effective in decreasing serum uric acid… read more here.
Keywords: uremic syndrome; rasburicase; syndrome related; related shiga ... See more keywords
Interleukin-33/ST2 signaling contributes to the severity of hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-018-1675-y
Abstract: ObjectivesInterleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33’s role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also… read more here.
Keywords: serum sst2; uremic syndrome; induced enterohemorrhagic; serum ... See more keywords
Clinical characteristics of children with hemolytic uremic syndrome in Hangzhou, China
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DOI: 10.1007/s12519-017-0021-x
Abstract: BackgroundHemolytic uremic syndrome (HUS) is a main cause of acute renal failure in children. This study aimed to analyze the clinical characteristics of HUS.MethodsA retrospective analysis was performed in 46 children with sporadic HUS.ResultsOf the… read more here.
Keywords: characteristics children; uremic syndrome; children hemolytic; hemolytic uremic ... See more keywords
Atypical hemolytic uremic syndrome due to DGKE mutation and response to eculizumab: lessons for the clinical nephrologist
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DOI: 10.1007/s40620-020-00925-8
Abstract: An 18-month-old white boy presented with non-bloody diarrhea and pallor and one week of cough and nasal congestion. On examination, he was hypertensive (115/99) and tachycardic (140 bpm). Pertinent labs included normocytic hemolytic anemia with… read more here.
Keywords: atypical hemolytic; uremic syndrome; hemolytic uremic; eculizumab ... See more keywords
Eculizumab treatment in atypical hemolytic uremic syndrome: correlation between functional complement tests and drug levels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nephrology"
DOI: 10.1007/s40620-021-01187-8
Abstract: Atypical hemolytic uremic syndrome (aHUS) is characterized by platelet consumption, hemolysis, and renal injury. Eculizumab, a humanized antibody that blocks complement activity, has been successfully used in aHUS, but the best treatment schedule has not… read more here.
Keywords: atypical hemolytic; drug; hemolytic uremic; treatment ... See more keywords
Hemolytic Uremic Syndrome
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DOI: 10.1007/s40746-020-00216-1
Abstract: The emergence of specific treatment of atypical hemolytic uremic syndrome (aHUS) using eculizumab has allowed renal function recovery and safe kidney transplantation (KT). Early and precise recognition of complement-mediated (CM) atypical HUS (aHUS) is challenging… read more here.
Keywords: hus; uremic syndrome; treatment; hemolytic uremic ... See more keywords
Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes
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DOI: 10.1016/b978-0-12-813456-6.00042-4
Abstract: Abstract Thrombotic thrombocytopenic purpura, Shiga toxin-associated hemolytic-uremic syndrome and atypical hemolytic-uremic syndrome often present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. These disorders are often classified as thrombotic microangiopathies, which in turn are considered synonymous… read more here.
Keywords: thrombocytopenic purpura; maha thrombocytopenia; thrombotic thrombocytopenic; hemolytic uremic ... See more keywords