Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2016.12.013
Abstract: Proinflammatory cytokines, including TNF-α and IL-6, can contribute to insulin resistance. Conversely, insulin has some actions that can be considered anti-inflammatory. Hemopexin is a Class 2 acute phase reactant and control of its transcription is… read more here.
Keywords: anti inflammatory; insulin; hemopexin; hemopexin mrna ... See more keywords
Effect of hemopexin treatment on outcome after intracerebral hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2021.147507
Abstract: Heme release from hemoglobin may contribute to secondary injury after intracerebral hemorrhage (ICH). The primary endogenous defense against heme toxicity is hemopexin, a 57 kDa glycoprotein that is depleted in the CNS after hemorrhagic stroke.… read more here.
Keywords: hemopexin treatment; hemopexin; heme; intracerebral hemorrhage ... See more keywords
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108181
Abstract: SUMMARY Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression. Labile heme and Hx levels are inversely correlated in the plasma… read more here.
Keywords: hemopexin; heme; cancer; growth metastases ... See more keywords
Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102009
Abstract: Triggering factors of Acute Chest Syndrome (ACS) is a leading cause of death in patients with Sickle Cell Disease (SCD) and targeted therapies are limited. Chlorine (Cl2) inhalation happens frequently, but its role as a… read more here.
Keywords: hemopexin; hemolysis; scd mice; mice ... See more keywords
Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions
Sign Up to like & getrecommendations! Published in 2017 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.7b00758
Abstract: A lack of target specificity has greatly hindered the success of inhibitor development against matrix metalloproteinases (MMPs) for the treatment of various cancers. The MMP catalytic domains are highly conserved, whereas the hemopexin-like domains of… read more here.
Keywords: hemopexin; hemopexin like; like domain; targeting hemopexin ... See more keywords
Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-140236
Abstract: Polymerization of hemoglobin-S (HbS) in the deoxy conformation shortens the lifespan of sickle red blood cells and promotes intravascular and extravascular hemolysis. When sickle red blood cells are lysed intravascularly, HbS is released into the… read more here.
Keywords: hemopexin; microvascular stasis; heme; model ... See more keywords
Revisiting the interaction of heme with hemopexin
Sign Up to like & getrecommendations! Published in 2021 at "Biological Chemistry"
DOI: 10.1515/hsz-2020-0347
Abstract: Abstract In hemolytic disorders, erythrocyte lysis results in massive release of hemoglobin and, subsequently, toxic heme. Hemopexin is the major protective factor against heme toxicity in human blood and currently considered for therapeutic use. It… read more here.
Keywords: hemopexin; revisiting interaction; heme; interaction heme ... See more keywords
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.901876
Abstract: Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of heme has been linked… read more here.
Keywords: heme; alternative pathway; hemopexin; factor ... See more keywords
Hemopexin and Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020997
Abstract: Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have highlighted its role in different kinds of heme-associated disorders, but its implication in cancer has been neglected for a long time.… read more here.
Keywords: hemopexin; hemopexin cancer; cancer; heme ... See more keywords
New Insights into Hemopexin-Binding to Hemin and Hemoglobin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073789
Abstract: Hemopexin (Hx) is a plasma glycoprotein that scavenges heme (Fe(III) protoporphyrin IX). Hx has important implications in hemolytic disorders and hemorrhagic conditions because releasing hemoglobin increases the labile heme, which is potentially toxic, thus producing… read more here.
Keywords: interaction; hemin hemoglobin; hemopexin; binding hemin ... See more keywords