Hemophagocytic Lymphohistiocytosis in Cutaneous T-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.1264
Abstract: Importance Hemophagocytic lymphohistiocytosis (HLH) has been reported as a serious complication of cutaneous T-cell lymphoma (CTCL). Despite available diagnostic guidelines, it remains a diagnostic and therapeutic challenge in this patient population. Objectives To examine the… read more here.
Keywords: cutaneous cell; hemophagocytic lymphohistiocytosis; cell; hlh ... See more keywords
High prevalence of osteonecrosis among the hemophagocytic lymphohistiocytosis population: Single institution 10‐year retrospective data review
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24828
Abstract: To the Editor: Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder that is characterized by overactive natural-killer and cytotoxic T cells that improperly trigger macrophages and subsequently leads to hemophagocytosis in bone marrow, spleen, liver, and… read more here.
Keywords: osteonecrosis; secondary hlh; diagnosis; prevalence ... See more keywords
A pilot study of the effect of atorvastatin on endothelial function and albuminuria in sickle cell disease
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25614
Abstract: 1. Henter JI, Horne A, Arico M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48(2):124-131. 2. U.S. Food and Drug Administration. Center for Drug Evaluation and Research. Imbruvica NDA… read more here.
Keywords: lymphocytic leukemia; lymphohistiocytosis; hemophagocytic lymphohistiocytosis; chronic lymphocytic ... See more keywords
Trigger‐dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis
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DOI: 10.1002/eji.201948123
Abstract: Familial hemophagocytic lymphohistiocytosis (FHL) is a hyperinflammatory syndrome affecting patients with genetic cytotoxicity defects. Perforin‐deficient (PKO) mice recapitulate the full clinical picture of FHL after infection with lymphocytic choriomeningitis virus (LCMV). Hyperactivated CD8+ T cells… read more here.
Keywords: dependent differences; hemophagocytic lymphohistiocytosis; infection; trigger dependent ... See more keywords
Adult onset hemophagocytic lymphohistiocytosis prognosis is affected by underlying disease and coexisting viral infection: analysis of a single institution series of 35 patients
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2314
Abstract: Adult onset hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which can develop as a complication of many disorders. Early diagnosis is essential in order to avoid a fatal outcome. To confirm the diagnosis of acquired… read more here.
Keywords: onset hemophagocytic; adult onset; institution series; hemophagocytic lymphohistiocytosis ... See more keywords
Outcomes of allogeneic hematopoietic stem cell transplantation for primary hemophagocytic lymphohistiocytosis in adults
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DOI: 10.1002/hon.3014
Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative approach for primary hemophagocytic lymphohistiocytosis (pHLH), but data on adult patients are scarce. Here we present an 8‐year experience on HSCT for adult pHLH to… read more here.
Keywords: hsct; allogeneic hematopoietic; adult; hemophagocytic lymphohistiocytosis ... See more keywords
The diagnostic importance of multiple cytokines in adult hemophagocytic lymphohistiocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24669
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a category of immunological illnesses that cause out‐of‐control T cells and macrophages to release life‐threatening cytokines. The HLH‐2004 diagnostic criteria are the gold standard for HLH diagnosis, but there is a… read more here.
Keywords: lymphohistiocytosis; hemophagocytic lymphohistiocytosis; diagnostic importance; multiple cytokines ... See more keywords
Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5mr0622-037r
Abstract: Inborn errors of immunity are a group of genetic disorders caused by mutations that affect the development and/or function of several compartments of the immune system, predisposing patients to infections, autoimmunity, allergy and malignancies. In… read more here.
Keywords: inborn errors; review; hemophagocytic lymphohistiocytosis; case ... See more keywords
Posttransplant Hemophagocytic Lymphohistiocytosis in Pediatric Liver Transplant Recipients
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DOI: 10.1002/lt.25951
Abstract: Hemophagocytic lymphohistiocytosis (HLH) refers to the life-threatening syndrome of pathologic immune activation, with a characteristic constellation of clinical findings comprising prolonged fever, splenomegaly, cytopenias, elevated inflammatory markers, and hemophagocytosis (HP).(1) It has been reported to… read more here.
Keywords: liver; hemophagocytic lymphohistiocytosis; posttransplant hemophagocytic; lymphohistiocytosis pediatric ... See more keywords
Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04095-2
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory disorder. We found recently that repeated lipopolysaccharide (LPS) treatment induces HLH-like features in senescence-accelerated mice (SAMP1/TA-1) but not in senescence-resistant control mice (SAMR1). In this study, we… read more here.
Keywords: hematopoiesis; dynamics hematopoiesis; hemophagocytic lymphohistiocytosis; factor ... See more keywords
A Case of Chronic Lymphocytic Leukemia Complicated by Hemophagocytic Lymphohistiocytosis: Identifying the Aberrant Immune Response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-022-07395-7
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that may complicate hematologic malignancies. HLH and malignancies have common clinical features, and HLH diagnostic criteria (HLH-2004/Hscore) were not validated in this specific population. We describe a… read more here.
Keywords: hlh; chronic lymphocytic; case; hemophagocytic lymphohistiocytosis ... See more keywords