Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_21
Abstract: Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in… read more here.
Keywords: hemophilia; factor viii; chromogenic factor; diagnosis ... See more keywords
The neurosurgical management of Severe Hemophilia A and Moyamoya (SHAM): challenges, strategies, and literature review
Sign Up to like & getrecommendations! Published in 2022 at "Child's Nervous System"
DOI: 10.1007/s00381-022-05489-5
Abstract: Severe Hemophilia A and Moyamoya arteriopathy (SHAM syndrome) is a rare genetic disorder caused by deletion of portions of the cytogenic band Xq28. A case of SHAM syndrome requiring bilateral cerebral revascularization is described with… read more here.
Keywords: hemophilia moyamoya; sham syndrome; severe hemophilia; hemophilia ... See more keywords
Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02639-5
Abstract: Bleeding into the joints represents the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). In a reproducible hemarthrosis mouse model, we found distinct changes in thrombin activity in joint tissue homogenate… read more here.
Keywords: hemarthrosis; thrombin activity; clotting factor; hemophilia ... See more keywords
Septic Arthritis in Pediatric Hemophilia A: A Case Report and Review of Literature.
Sign Up to like & getrecommendations! Published in 2022 at "Indian journal of orthopaedics"
DOI: 10.1007/s43465-021-00565-5
Abstract: Hemophilia A is a hereditary bleeding disorder due to coagulation factor VIII deficiency. Septic arthritis is in itself a dreaded infective condition of the joint. It is much more common in hemophilia patients than the… read more here.
Keywords: literature; arthritis pediatric; hemophilia; case ... See more keywords
Improving assessment and management of pain in hemophilia: an Italian Delphi consensus statement.
Sign Up to like & getrecommendations! Published in 2021 at "Blood reviews"
DOI: 10.1016/j.blre.2021.100885
Abstract: Comprehensive evidence-based guidelines and well-validated assessment scales for pain in people with hemophilia (PwH) are needed. Here, we report 28 statements covering five topics on pain assessment and management in pediatric and adult PwH that… read more here.
Keywords: consensus; assessment management; delphi consensus; hemophilia ... See more keywords
Radical Cystectomy with Ileal Neobladder in a patient with Hemophilia! A case report
Sign Up to like & getrecommendations! Published in 2020 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2020.101313
Abstract: A 38 year old hepatitis C and Hemophilia Type A patient presented with recurrent hematuria since 6 months. Investigations revealed a 5 cm lesion in the lateral wall of the bladder with perivesical fat stranding.… read more here.
Keywords: case; cystectomy ileal; radical cystectomy; hemophilia ... See more keywords
PP147 Physician And Patient Reported Anxiety And Depression In Hemophilia
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s0266462317002902
Abstract: INTRODUCTION: Anxiety and depression are major drivers of health-related quality of life, adherence to therapy, and motivation to self-manage chronic conditions. A number of studies have shown rates of anxiety and depression to be higher… read more here.
Keywords: depression; physician patient; percent; anxiety depression ... See more keywords
Activation of the Acute-Phase Response in Hemophilia
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2071-0477
Abstract: To identify recurrent inflammation in hemophilia, we assessed the acute-phase response in the blood of patients with hemophilia A and B. Compared to age- and weight-matched controls, blood levels of interleukin-6 (IL-6), C-reactive protein (CRP)… read more here.
Keywords: phase response; hemophilia patients; acute phase; hemophilia ... See more keywords
Assessing the potential cost-effectiveness of a gene therapy for the treatment of hemophilia A
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DOI: 10.1080/13696998.2020.1721508
Abstract: Abstract Aim: Hemophilia A is a genetic, chronic disorder classified by deficient or defective coagulation factor VIII (FVIII) that puts those affected at risk for spontaneous bleeding episodes, which lead to joint damage and chronic… read more here.
Keywords: treatment; gene therapy; therapy; hemophilia ... See more keywords
Simoctocog alfa for the treatment of hemophilia A
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2017.1391785
Abstract: ABSTRACT Introduction: Hemophilia A is the most frequent inherited bleeding disorder and most challenging coagulation disorder. To combat this, a number of new improved rFVIII/IX concentrates have recently been approved. Some of them are derived… read more here.
Keywords: simoctocog; alfa treatment; expert opinion; simoctocog alfa ... See more keywords
Re-personalization and stratification of hemophilia care in an evolving treatment landscape
Sign Up to like & getrecommendations! Published in 2019 at "Hematology"
DOI: 10.1080/16078454.2019.1687798
Abstract: ABSTRACT Hemophilia therapeutics are evolving rapidly. Comprehensive care must also evolve to embrace this change. Online tools and guidelines are widely available to optimize prophylaxis with conventional clotting factor concentrates using an individual's predicted pharmacokinetic… read more here.
Keywords: treatment; landscape; personalization stratification; hemophilia ... See more keywords