Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02639-5
Abstract: Bleeding into the joints represents the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). In a reproducible hemarthrosis mouse model, we found distinct changes in thrombin activity in joint tissue homogenate… read more here.
Keywords: hemarthrosis; thrombin activity; clotting factor; hemophilia ... See more keywords
Epitope Dependent Augmentation of the Immune Response in Hemophilia Α Mice Immunized with Factor VIII/Antibody Immune Complexes
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DOI: 10.1182/blood-2019-127436
Abstract: Introduction: The immune response to factor VIII (fVIII) is a CD4+ T cell dependent process initiated by fVIII recognition and processing by antigen presenting cells. The C1 and C2 domains have been proposed as the… read more here.
Keywords: mice immunized; fviii; board; immune response ... See more keywords
Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006214
Abstract: Key Points We generated novel hemophilia A or B mice expressing human protein C. Selectively blocking the anticoagulant activity of human activated protein C improves the clotting defects in hemophilia mice. read more here.
Keywords: human protein; mice expressing; expressing human; anticoagulant activity ... See more keywords