Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives
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DOI: 10.1007/s11172-017-1914-5
Abstract: New 4-aryl-2-(4-arylamino)-1-(piperazin-1-yl)but-2-ene-1,4-diones and 2-{[2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-(het)aryl-4-oxobut-2-enoic acids were synthesized and used to obtain water-soluble compounds. Their influence on the blood coagulation system was studied, which revealed compounds with a high hemostatic activity and a low acute toxicity.… read more here.
Keywords: oxobut enoic; aryl oxobut; hemostatic activity; het aryl ... See more keywords
Cytotoxicity and hemostatic activity of chitosan/carrageenan composite wound healing dressing for traumatic hemorrhage.
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DOI: 10.1016/j.carbpol.2020.116106
Abstract: Hemorrhage remains a big threat to trauma patients, especially in combat fields. Therefore, we formulated a biocompatible and biopolymer based chitosan/carrageenan composite dressing. This dressing was fabricated using freeze-drying that will serve as a promising… read more here.
Keywords: wound healing; hemostatic activity; hemorrhage; chitosan carrageenan ... See more keywords
Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications
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DOI: 10.1126/scitranslmed.aay0203
Abstract: In select platelet disorders, dysfunctional endogenous platelets affect the hemostatic activity of transfused platelets by multiple mechanisms. Strength in numbers (of platelets) Platelet transfusions are effective at restoring hemostasis in patients with low platelet counts,… read more here.
Keywords: acquired platelet; hemostatic activity; transfused platelets; platelet disorders ... See more keywords