Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in Acute Hyperlipidemia Mouse Model
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5741
Abstract: Hovenia dulcis Thunb. (HDT) was known to have anti‐fatigue, anti‐diabetes, neuroprotective, and hepatoprotective effects. In the present study, the anti‐fatty liver mechanism of HDT was elucidated in oleic acid (OA)‐treated Hep G2 cells and acute… read more here.
Keywords: hyperlipidemia; lipid accumulation; hep cells; acute hyperlipidemia ... See more keywords
Combining multi-antigenic immunodot with indirect immunofluorescence on HEp-2 cells improves the diagnosis of systemic sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical immunology"
DOI: 10.1016/j.clim.2021.108774
Abstract: Systemic sclerosis (SSc) is associated, in nearly all patients, with autoantibodies (Ab). Accordingly, and in order to identify major (anti-CEN A/B and anti-Topo I) but also minor Abs, the usefulness of combining indirect immunofluorescence (IIF)… read more here.
Keywords: ssc; indirect immunofluorescence; multi antigenic; hep ... See more keywords
Luteolin induces caspase‐dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK‐Hep‐1 cells
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.08.025
Abstract: Aims: Luteolin, a naturally occurring flavonoid, possesses anti‐cancer effects including induction of apoptosis. This study investigated the involvement of osteopontin (OPN) in luteolin‐induced apoptosis in human hepatocellular carcinoma (HCC) SK‐Hep‐1 cells with high OPN expression.… read more here.
Keywords: cell; apoptosis; hep cells; expression ... See more keywords
Brusatol inhibits laryngeal cancer cell proliferation and metastasis via abrogating JAK2/STAT3 signaling mediated epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119907
Abstract: AIMS This study aimed at investigating the role of Brusatol (BR) on human laryngeal squamous carcinoma cell (Hep-2) to study its underlying mechanism through in vitro and in vivo approaches. MATERIALS AND METHOD In the… read more here.
Keywords: jak2 stat3; cell proliferation; hep; study ... See more keywords
Triple quadrupole mass spectrometry comparative DNA adductomics of Hep G2 cells following exposure to safrole.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.10.023
Abstract: A DNA adduct screening pipeline was constructed to apply triple quadrupole mass spectrometry comparative DNA adductomics to investigate the effects of the naturally-occurring plant constituent, safrole (4-allyl-1,2-methylenedioxybenzene), on human hepatoma cells, Hep G2. DNA from… read more here.
Keywords: mass spectrometry; dna; comparative dna; hep cells ... See more keywords
IFNgamma-inducible CXCL10/CXCR3 axis alters the sensitivity of HEp-2 cells to ionizing radiation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112382
Abstract: Radiotherapy is a conventional approach for anti-cancer treatment, killing tumor cells through damaging cellular DNA. While increasing studies have demonstrated that tumors generated the tolerance to radiation and tumor immune system was found to be… read more here.
Keywords: cxcr3; hep cells; ifngamma; cxcl10 ... See more keywords
Rare immunofluorescence patterns of autoantibodies on HEp-2 cells defined by ICAP identify different autoimmune diseases in the absence of associated specificities: a Spanish multicentre study.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa831
Abstract: OBJECTIVES ANA are the most extensively used test for the diagnosis of systemic autoimmune diseases. However, testing by indirect immunofluorescence assays (IIFAs) on HEp-2 cells, the gold standard test, is time-consuming and needs expertise. Thus… read more here.
Keywords: associated specificities; hep cells; autoimmune diseases; immunofluorescence ... See more keywords
Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s183859
Abstract: Background Glucose transporter (GLUT)-mediated glucose uptake is an important process in the development of laryngeal carcinoma, one of the most common malignancies of the head and neck. GLUT-1, together with HIF-1α, is also an indicator… read more here.
Keywords: hif; gene knockout; hif glut; hep cells ... See more keywords
Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
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DOI: 10.2147/dddt.s166051
Abstract: Background The structural modification of natural products with the aim to improve the anticancer activity is a popular current research direction. The pentacyclic triterpenoid compounds oleanolic acid (OA) and glycyrrhetinic acid (GA) are distributed widely… read more here.
Keywords: glycyrrhetinic acids; ic50 value; hep cells; compound ... See more keywords
Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s177126
Abstract: Background Tyroserleutide (YSL) inhibits the growth and metastasis of human hepatocellular carcinoma (HCC). This paper studied the effect of YSL on metastasis of human HCC and investigated its mechanisms. Methods In vivo, experimental lung metastasis… read more here.
Keywords: hepatocellular carcinoma; metastasis human; hep; metastasis ... See more keywords
Omega-3 polyunsaturated fatty acid inhibits the malignant progression of hepatocarcinoma by inhibiting the Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201807_15504
Abstract: OBJECTIVE Omega-3 polyunsaturated fatty acid (ω-3 PUFA) has been found to possess anti-cancer potential in previous studies. However, the underlying mechanism of ω-3 PUFA in protecting hepatocarcinoma has not been fully elucidated. This study aims… read more here.
Keywords: pufa; hepatocarcinoma; hep cells; mol ... See more keywords