The contribution of toll‐like receptor signaling to the development of liver fibrosis and cancer in hepatocyte‐specific TAK1‐deleted mice
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DOI: 10.1002/ijc.31029
Abstract: Hepatocyte death is associated with liver inflammation, fibrosis and hepatocellular carcinoma (HCC). Damaged cells trigger inflammation through activation of Toll‐like receptors (TLRs). Although the role of TLR4 in HCC development has been reported, the role… read more here.
Keywords: tak1; fibrosis; hep mice; tak1 hep ... See more keywords
Feedback repression of PPARα signaling by Let-7 microRNA
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DOI: 10.1016/j.celrep.2021.109506
Abstract: SUMMARY Peroxisome proliferator-activated receptor α (PPARα) controls hepatic lipid homeostasis and is the target of lipid-lowering fibrate drugs. PPARα activation represses expression of let-7 microRNA (miRNA), but the function of let-7 in PPARα signaling and… read more here.
Keywords: ppar signaling; let microrna; hep mice; let7b hep ... See more keywords