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   Articles with "hep3b" as a keyword



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Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-39778-y

Abstract: This study demonstrated that fenofibrate, a lipid-lowering drug, induced a significant time-dependent cytotoxicity of hepatoma Hep3B cells. Hep3B cells are significantly more sensitive to cell killing by fenofibrate than hepatoma HepG2, lung cancer CH27 and… read more here.

Keywords: thioesterase domain; fatty acid; domain fatty; hep3b ... See more keywords

Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants.

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recommendations! Published in 2019 at "Glycobiology"

DOI: 10.1093/glycob/cwz037

Abstract: Binding and uptake of triglyceride-rich lipoproteins (TRLs) in mice depends on heparan sulfate and hepatic proteoglycan, syndecan-1. Alteration of glucosamine N-sulfation by deletion of glucosamine N-deacetylase-N-sulfotransferase 1 (Ndst1) and 2-O-sulfation of uronic acids by deletion… read more here.

Keywords: heparan sulfate; sulfation; hep3b; binding uptake ... See more keywords

PD173074 blocks G1/S transition via CUL3-mediated ubiquitin protease in HepG2 and Hep3B cells

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0234708

Abstract: Fibroblast growth factor receptors (FGFRs) are frequently altered in a variety of human cancer cells and are overexpressed in hepatocellular carcinoma (HCC). Several literatures have proven that they are efficacious for HCC therapy, however, the… read more here.

Keywords: hcc; hep3b; cul3; hep3b cells ... See more keywords
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Associations of DDX60L With the Clinical Features and Prognosis of Hepatocellular Carcinoma

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.761021

Abstract: Objective Although the pathogenesis of hepatocellular carcinoma (HCC) is still unclear, hepatitis C virus (HCV) infection is considered a common cause of HCC. It has been reported that DDX60L can inhibit HCV replication, but its… read more here.

Keywords: hepatocellular carcinoma; hep3b; ddx60l; hcc ... See more keywords