Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Blood Pressure and Atherosclerosis in Mice—Brief Report
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.314048
Abstract: Supplemental Digital Content is available in the text. Objective: Renin cleavage of angiotensinogen has species specificity. As the residues at positions 11 and 12 are different between human angiotensinogen and mouse angiotensinogen, we determined whether… read more here.
Keywords: mice; blood pressure; mouse angiotensinogen; hepagt mice ... See more keywords
Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis[S]
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m093252
Abstract: Nonalcoholic fatty liver disease (NAFLD) is considered as a liver manifestation of metabolic disorders. Previous studies indicate that the renin-angiotensin system (RAS) plays a complex role in NAFLD. As the only precursor of the RAS,… read more here.
Keywords: western diet; liver steatosis; hepagt mice; mice ... See more keywords