Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate Polymers"
DOI: 10.1016/j.carbpol.2021.117797
Abstract: Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world. Although a vaccine has recently been approved, there are currently few effective therapeutics… read more here.
Keywords: heparan sulfate; human lung; respiratory; sars cov ... See more keywords
Intrathecal heparan-N-sulfatase in patients with Sanfilippo syndrome type A: A phase IIb randomized trial.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2018.10.006
Abstract: BACKGROUND Sanfilippo syndrome type A (mucopolysaccharidosis type IIIA) is a lysosomal disorder wherein deficient heparan-N-sulfatase (HNS) activity results in the accumulation of heparan sulfate in the central nervous system and is associated with progressive neurodegeneration… read more here.
Keywords: trial; syndrome type; heparan sulfatase; sanfilippo syndrome ... See more keywords
Immunogenic Sulfated l-Idose Homo Oligosaccharides Elicit Neutralizing Antibody against Native Heparan Sulfate with Biomarker and Therapeutic Possibilities.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01772
Abstract: Heparan sulfate (HS) is a non-immunogenic antigen, and developing antibodies against specific sulfated patterns in HS poses significant challenges. Herein, we employed an innovative immunization strategy that exploits the molecular mimicry of HS to generate… read more here.
Keywords: heparan sulfate; heparan; antibody; immunogenic sulfated ... See more keywords
Construction and characterisation of a heparan sulphate heptasaccharide microarray.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08204a
Abstract: A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The… read more here.
Keywords: heparan sulphate; microarray; characterisation heparan; construction characterisation ... See more keywords
The role of heparan sulfate in host macrophage infection by Leishmania species.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170398
Abstract: The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous… read more here.
Keywords: infection; leishmania species; role; host ... See more keywords
A 6-O-endosulfatase activity assay based on synthetic Heparan Sulfate oligomers.
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad026
Abstract: Sulf-2 is an extracellular heparan 6-O-endosulfatase involved in the post-synthetic editing of heparan sulfate which regulates many important biological processes. Activity of the Sulf-2 and its substrate specificity remain insufficiently characterized in spite of more… read more here.
Keywords: heparan; heparan sulfate; synthetic heparan; endosulfatase activity ... See more keywords
Diversity of human salivary heparan sulfate.
Sign Up to like & getrecommendations! Published in 2024 at "Glycobiology"
DOI: 10.1093/glycob/cwae084
Abstract: The human oral cavity and upper airway serves as an early barrier and reservoir in the transmission of SARS-CoV-2. Saliva in this microenvironment may serve as a key host factor that can modulate susceptibility to… read more here.
Keywords: heparan sulfate; heparan; history; composition ... See more keywords
Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.01181-21
Abstract: Vascular glycocalyx remodeling is critical to sepsis pathology, but the glycocalyx components that contribute to this process remain poorly characterized. This article shows that during Staphylococcus aureus sepsis, the liver vascular glycocalyx undergoes dramatic compositional… read more here.
Keywords: glycocalyx; heparan; heparan sulfate; aureus sepsis ... See more keywords
The Effect of a Synthetic Heparan Sulfate on the Healing of Colonic Anastomoses
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology Research and Practice"
DOI: 10.1155/2017/1078062
Abstract: Background The mimetic compound OTR4120 may replace endogenous-degraded heparan sulfates that normally maintain the bioactivity of growth factors that are important for tissue repair. Herein, we investigated the effect of OTR4120 on the healing of… read more here.
Keywords: synthetic heparan; effect synthetic; heparan sulfate; colonic anastomoses ... See more keywords
Differential regulation of heparan sulfate biosynthesis in fibroblasts cocultured with normal vs. cancerous prostate cells
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1440623
Abstract: Heparan sulfate proteoglycans (HSPGs) regulate a wide range of biological activities in both physiological and pathological conditions. Altered expression or deregulated function of HSPGs and their heparan sulfate (HS) chains significantly contribute to carcinogenesis as… read more here.
Keywords: heparan sulfate; heparan; prostate; biosynthesis ... See more keywords
Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14225553
Abstract: Simple Summary 6-O-endosulfatases, SULF1 and SULF2, are oncogenic in multiple malignancies and are associated with poor survival outcomes. SULF1 is one of the most consistently unregulated enzymes in HNSCC tissues even though its expression in… read more here.
Keywords: cell; heparan; sulf1 sulf2; endosulfatases sulf1 ... See more keywords