Prognostic significance of hedgehog signaling network‐related gene expression in breast cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29886
Abstract: Breast cancer continues to be a serious public health problem. The role of the hedgehog pathway in normal development of the mammary gland as well as in carcinogenesis and progression of breast cancer is the… read more here.
Keywords: heparan sulfate; prognosis; expression; breast cancer ... See more keywords
Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1398-6_53
Abstract: In this chapter, we describe the detection of the glycosaminoglycans hyaluronan and heparan sulfate in pancreatic islets and lymphoid tissues. The identification of hyaluronan in tissues is achieved by utilizing a highly specific hyaluronan binding… read more here.
Keywords: detection glycosaminoglycans; hyaluronan; heparan sulfate; tissue ... See more keywords
Involvement of Heparan Sulfate and Heparanase in Neural Development and Pathogenesis of Brain Tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-34521-1_14
Abstract: Brain tumors are aggressive and devastating diseases. The most common type of brain tumor, glioblastoma (GBM), is incurable and has one of the worst five-year survival rates of all human cancers. GBMs are invasive and… read more here.
Keywords: heparan sulfate; brain tumors; involvement heparan; brain ... See more keywords
Heparanase in Kidney Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-34521-1_26
Abstract: The primary filtration of blood occurs in the glomerulus in the kidney. Destruction of any of the layers of the glomerular filtration barrier might result in proteinuric disease. The glomerular endothelial cells and especially its… read more here.
Keywords: heparanase; kidney; heparan sulfate; heparanase kidney ... See more keywords
Expression and purification of recombinant extracellular sulfatase HSulf-2 allows deciphering of enzyme sub-domain coordinated role for the binding and 6-O-desulfation of heparan sulfate
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03027-2
Abstract: Through their ability to edit 6-O-sulfation pattern of Heparan sulfate (HS) polysaccharides, Sulf extracellular endosulfatases have emerged as critical regulators of many biological processes, including tumor progression. However, study of Sulfs remains extremely intricate and… read more here.
Keywords: expression purification; recombinant; domain; heparan sulfate ... See more keywords
Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-022-01854-w
Abstract: In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS)… read more here.
Keywords: glycocalyx; heparan sulfate; ext1 ext2; endothelial glycocalyx ... See more keywords
Changes in heparan sulfate sulfotransferases and cell-surface heparan sulfate during SKM-1 cells granulocytic differentiation and A549 cells epithelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09903-0
Abstract: Heparan sulfate (HS) with various sulfation patterns is one of important modulators of cancer cell fate through interacting with numerous growth factors. Here we found HS 2-O sulfotransferase 1 (HS2ST1) was downregulated at both mRNA… read more here.
Keywords: mesenchymal transition; sulfate; heparan sulfate; epithelial mesenchymal ... See more keywords
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
Sign Up to like & getrecommendations! Published in 2021 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-021-10018-8
Abstract: Furin is one of the nine-member proprotein convertase family. Furin cleaves proteins with polybasic residues, which includes many viral glycoproteins such as SARS-Cov-2 spike protein. The cleavage is required for the activation of the proteins.… read more here.
Keywords: structural characteristics; heparan sulfate; furin; sulfation ... See more keywords
Heparan sulfate storage in the cardiac conduction system triggers atrioventricular block
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DOI: 10.1016/j.braindev.2016.12.008
Abstract: OBJECTIVE To elucidate the novel biological functions of heparan sulfate (HS) by clinic-pathologically studying a patient with paroxysmal atrioventricular (AV) block. PATIENT A long-surviving male patient with Sanfilippo syndrome type A presented with paroxysmal AV… read more here.
Keywords: storage; cardiac conduction; block; atrioventricular block ... See more keywords
Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate Polymers"
DOI: 10.1016/j.carbpol.2021.117797
Abstract: Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world. Although a vaccine has recently been approved, there are currently few effective therapeutics… read more here.
Keywords: heparan sulfate; human lung; respiratory; sars cov ... See more keywords
Heparan sulfate from porcine mucosa promotes amyloid-beta clearance in APP/PS1 mice and alleviates Alzheimer's pathology.
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DOI: 10.1016/j.carbpol.2022.119205
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive impairments. Amyloid-β (Aβ) deposition and neurotoxicity play important roles in AD. It has been widely reported that heparan sulfate (HS) proteoglycans play… read more here.
Keywords: pathology; ps1 mice; porcine mucosa; heparan sulfate ... See more keywords