Cloning and bacterial expression systems for recombinant human heparanase production: Substrate specificity investigation by docking of a putative heparanase substrate
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1582
Abstract: Human heparanase (HPSE) is an enzyme that degrades the extracellular matrix. It is implicated in a multiplicity of physiological and pathological processes encouraging angiogenesis and tumor metastasis. The protein is a heterodimer composed of a… read more here.
Keywords: heparanase; substrate; substrate specificity; expression ... See more keywords
4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200580
Abstract: Degradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM‐remodeling enzyme with β‐D‐endo‐glucuronidase activity overexpressed in several malignancies, and… read more here.
Keywords: substituted glucuronic; hpse; glucuronic cyclophellitols; cyclophellitols selective ... See more keywords
Heparanase‐1 activity and the early postnatal prostate development
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Dynamics"
DOI: 10.1002/dvdy.12
Abstract: Ventral prostate (VP) morphogenesis starts during embryonic development and continues for the first three postnatal weeks. Heparan sulfate (HS) affects paracrine signaling. Heparanase‐1 (HPSE) is the only enzyme capable of cleaving HS. HPSE releases the… read more here.
Keywords: prostate; heparanase; hpse; epithelial growth ... See more keywords
Microenvironment modulation and enhancement of antilymphoma therapy by the heparanase inhibitor roneparstat
Sign Up to like & getrecommendations! Published in 2018 at "Hematological Oncology"
DOI: 10.1002/hon.2466
Abstract: The standard management of diffuse large B‐cell lymphoma (DLBCL) relies on the chemotherapy combination including cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Although the introduction of anti‐CD20 monoclonal antibody rituximab with CHOP chemotherapy has demonstrated a… read more here.
Keywords: combination; heparanase; inhibitor roneparstat; heparanase inhibitor ... See more keywords
Potential roles of heparanase in cancer therapy: Current trends and future direction
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30995
Abstract: Heparanase (HPSE; heparanase‐1) is an endo‐β‐glucuronidase capable of degrading the carbohydrate moiety of heparan sulfate proteoglycans, thus modulating and facilitating the remodeling of the extracellular matrix and basement membrane. HPSE activity is strongly associated with… read more here.
Keywords: hpse; potential roles; heparanase; roles heparanase ... See more keywords
Heparanase is a regulator of natural killer cell activation and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.3a0420-259rr
Abstract: Heparanase is the only mammalian enzyme capable of cleaving heparan sulfate, a glycosaminoglycan of the extracellular matrix and cell surfaces. Most immune cells express heparanase that contributes to a range of functions including cell migration… read more here.
Keywords: cytotoxicity; cell activation; heparanase; hpse ... See more keywords
Role of Heparanase in Macrophage Activation.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-34521-1_17
Abstract: Macrophages represent one of the most diverse immunocyte populations, constantly shifting between various phenotypes/functional states. In addition to execution of vital functions in normal physiological conditions, macrophages represent a key contributing factor in the pathogenesis… read more here.
Keywords: heparanase macrophage; heparanase; macrophage activation; role heparanase ... See more keywords
Heparanase in Kidney Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-34521-1_26
Abstract: The primary filtration of blood occurs in the glomerulus in the kidney. Destruction of any of the layers of the glomerular filtration barrier might result in proteinuric disease. The glomerular endothelial cells and especially its… read more here.
Keywords: heparanase; kidney; heparan sulfate; heparanase kidney ... See more keywords
Production of heparin and λ-carrageenan anti-heparanase derivatives using a combination of physicochemical depolymerization and glycol splitting.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.02.040
Abstract: Strongly associated with tumor angiogenesis and metastasis, the enzyme heparanase is an endo-β-d-glucuronidase which is overexpressed in the tumor microenvironment. Its inhibition could be one of the most promising anti-angiogenic approaches to date. Although heparin… read more here.
Keywords: heparanase; heparin; anti heparanase; glycol splitting ... See more keywords
Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2018.05.013
Abstract: OBJECTIVES The chondrocytes' pericellular matrix acts as a mechanosensor by sequestering growth factors that are bound to heparan sulfate (HS) proteoglycans. Heparanase is the sole mammalian enzyme with HS degrading endoglycosidase activity. Here, we aimed… read more here.
Keywords: heparanase; primary chondrocytes; adult human; osteoarthritic cartilage ... See more keywords
Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b17625
Abstract: Heparanase, the heparan sulfate polysaccharide degrading endoglycosidase enzyme, has been correlated with tumor angiogenesis and metastasis and therefore has become a potential target for anticancer drug development. In this systematic study, the sulfation pattern of… read more here.
Keywords: glycopolymer; heparanase; sulfation pattern; metastasis ... See more keywords