Corrigendum to: Recent advances in the discovery of heparanase inhibitors as anti-cancer agents [Eur. J. Mech. 121 (2016) 209-220].
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.092
Abstract: The authors regret that the Graphical Abstract on p. vii, and Fig. 2, on p. 212 contain incorrect structures and apologise for any inconvenience caused. The correct structures are shown below in the Graphical Abstract… read more here.
Keywords: discovery heparanase; anti cancer; heparanase inhibitors; advances discovery ... See more keywords
Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo
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DOI: 10.1073/pnas.2203167119
Abstract: Significance Cancer growth is accompanied by changes to the extracellular environment of tumors, which aids the proliferation and spread of cancer cells. Cancer-associated extracellular matrix changes include excessive degradation of heparan sulfate carbohydrates, promoting metastatic… read more here.
Keywords: metastasis; mechanism based; based heparanase; heparanase inhibitors ... See more keywords
New classes of potent heparanase inhibitors from ligand-based virtual screening
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DOI: 10.1080/14756366.2020.1811701
Abstract: Abstract Heparanase is a validated target in cancer therapy and a potential target for several inflammatory pathologies. A ligand-based virtual screening of commercial libraries was performed to expand the chemical space of small-molecule inhibitors. The… read more here.
Keywords: virtual screening; ligand based; heparanase; based virtual ... See more keywords