Apoptosis in HepaRG and HL‐7702 cells inducted by polyphyllin II through caspases activation and cell‐cycle arrest
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27462
Abstract: Rhizoma Paridis, a traditional Chinese medicine, has shown promise in cancer prevention and therapy. Polyphyllin II is one of the most significant saponins in Rhizoma Paridis and it has toxic effects on kinds of cancer… read more here.
Keywords: apoptosis; cell cycle; heparg; caspases activation ... See more keywords
Setup and Use of HepaRG Cells in Cholestasis Research.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9420-5_19
Abstract: Since HepaRG cells can differentiate into well-polarized mature hepatocyte-like cells that synthesize, conjugate, and secrete bile acids, they represent an appropriate surrogate to primary human hepatocytes for investigations on drug-induced cholestasis mechanisms. In this chapter,… read more here.
Keywords: cells cholestasis; bile acids; setup use; heparg cells ... See more keywords
Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance
Sign Up to like & getrecommendations! Published in 2017 at "Human Cell"
DOI: 10.1007/s13577-017-0175-9
Abstract: HepaRG cells are widely used as an in vitro model to assess drug-induced hepatotoxicity. However, only few studies exist so far regarding their suitability to detect the effects of drugs requiring a preceding activation via… read more here.
Keywords: substance; heparg cells; heparg; drug induced ... See more keywords
3D culture of HepaRG cells in GelMa and its application to bioprinting of a multicellular hepatic model.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120611
Abstract: Bioprinting is an emergent technology that has already demonstrated the capacity to create complex and/or vascularized multicellular structures with defined and organized architectures, in a reproducible and high throughput way. Here, we present the implementation… read more here.
Keywords: culture heparg; heparg cells; cells gelma; heparg ... See more keywords
Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) signalling is involved in transdifferentiation of hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.280
Abstract: The identification of key regulators in hepatic progenitor cells differentiation is determinant for organ regeneration and may improve stem cell transplantation for end-stage liver disease. Mesenchymal, embryonic and pluripotent stem cells have been investigated as… read more here.
Keywords: transdifferentiation; heparg; differentiation; hepatocyte ... See more keywords
Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.01.010
Abstract: New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for… read more here.
Keywords: new psychoactive; zebrafish larvae; metabolism; heparg ... See more keywords
Toxicity and Metabolomic Impact of Cobalt, Chromium, and Nickel Exposure on HepaRG Hepatocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00429
Abstract: Cobalt, chromium, and nickel are used in orthopedic prostheses. They can be released, accumulate in many organs, and be toxic. The aim of this study is to evaluate the cytotoxicity of these metals on human… read more here.
Keywords: cobalt chromium; chromium nickel; heparg;
Functional polarization of human hepatoma HepaRG cells in response to forskolin
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34421-8
Abstract: HepaRG is an original human hepatoma cell line, acquiring highly differentiated hepatic features when exposed to dimethylsulfoxide (DMSO). To search alternatives to DMSO, which may exert some toxicity, we have analyzed the effects of forskolin… read more here.
Keywords: human hepatoma; functional polarization; heparg cells; heparg ... See more keywords
Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dietary supplements"
DOI: 10.1080/19390211.2022.2153957
Abstract: Methylsulfonylmethane (MSM), a natural organosulfur compound, is a popular dietary supplement sold both as a single product and as a constituent of multi-ingredient products. It has been postulated that MSM may serve as a donor… read more here.
Keywords: methyl groups; methylation; dna; dna methylation ... See more keywords
Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9050196
Abstract: Real-time monitoring of bioanalytes in organotypic cell cultivation devices is a major research challenge in establishing stand-alone diagnostic systems. Presently, no general technical facility is available that offers a plug-in system for bioanalytics in diversely… read more here.
Keywords: culture; cell culture; heparg cell; albumin secretion ... See more keywords
Redox-Dependent Modulation of Human Liver Progenitor Cell Line Fate
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031934
Abstract: Redox homeostasis is determinant in the modulation of quiescence/self-renewal/differentiation of stem cell lines. The aim of this study consisted of defining the impact of redox modifications on cell fate in a human hepatic progenitor line.… read more here.
Keywords: differentiation; modulation; cell line; heparg ... See more keywords