In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201018666171122124401
Abstract: BACKGROUND Identification of metabolites is of importance in the challenge of new psychoactive substances (NPS) as it could improve the detection window in biological matrices in clinical and forensic cases of intoxication. Considering the numerous… read more here.
Keywords: cell line; nps; furanyl fentanyl; heparg cell ... See more keywords
Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9050196
Abstract: Real-time monitoring of bioanalytes in organotypic cell cultivation devices is a major research challenge in establishing stand-alone diagnostic systems. Presently, no general technical facility is available that offers a plug-in system for bioanalytics in diversely… read more here.
Keywords: culture; cell culture; heparg cell; albumin secretion ... See more keywords
Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Toxins"
DOI: 10.3390/toxins10040154
Abstract: Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA). Bavachinin (BVC) is a natural product derived from the fruit of the traditional… read more here.
Keywords: p38 jnk; jnk; oxidative damage; drug ... See more keywords