Design of intelligent chitosan/heparin hollow microcapsules for drug delivery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.44425
Abstract: In this study, a novel strategy has been developed for the assembly of polyelectrolyte multilayer (PEM) on CaCO3 templates in acidic pH solutions, where consecutive polyelectrolyte layers (heparin/poly(allylamine hydrochloride) or heparin/chitosan) were deposited on PEM… read more here.
Keywords: chitosan; drug delivery; heparin; hollow microcapsules ... See more keywords
Pyrene‐Based Self‐Assembling Peptide for Ratiometric Detection of Heparin
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200652
Abstract: Heparin is a commonly used anticoagulant in clinical practice; however, excessive heparin can cause serious adverse reactions. Convenient and accurate detection of heparin levels is thus very important. In this research, a pyrene‐based self‐assembling fluorescent… read more here.
Keywords: ratiometric detection; heparin; detection; pyrene based ... See more keywords
Optimal protamine‐to‐heparin dosing ratio for the prevention of bleeding complications in patients undergoing TAVR—A multicenter experience
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cardiology"
DOI: 10.1002/clc.23936
Abstract: Despite major advances, transcatheter aortic valve replacement (TAVR) is still associated with procedure‐specific complications. Although previous studies reported lower bleeding rates in patients receiving protamine for heparin reversal, the optimal protamine‐to‐heparin dosing ratio is unknown. read more here.
Keywords: optimal protamine; heparin dosing; heparin; dosing ratio ... See more keywords
Heparin‐induced thrombocytopenia associated with collection of hematopoietic progenitor cells by apheresis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21757
Abstract: Heparin‐induced thrombocytopenia (HIT) can occur following exposure to heparin and is characterized by thrombocytopenia with increased risk for thrombosis. This condition is mediated by formation of immunoglobulin G antibodies against platelet factor 4/heparin complexes that… read more here.
Keywords: heparin; hematopoietic progenitor; induced thrombocytopenia; heparin induced ... See more keywords
Laboratory diagnosis of heparin‐induced thrombocytopenia: A retrospective experience
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24884
Abstract: Heparin‐induced thrombocytopenia (HIT) is a severe complication of heparin therapy associated with thrombosis that requires a quick diagnosis. Therefore, laboratory assays must provide an accurate and swift answer. This work aims to evaluate the performances… read more here.
Keywords: heparin; heparin induced; induced thrombocytopenia; laboratory diagnosis ... See more keywords
Heparin‐induced amyloid fibrillation of β2‐microglobulin explained by solubility and a supersaturation‐dependent conformational phase diagram
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3149
Abstract: Amyloid fibrils are fibrillar deposits of denatured proteins associated with amyloidosis and are formed by a nucleation and growth mechanism. We revisited an alternative and classical view of amyloid fibrillation: amyloid fibrils are crystal‐like precipitates… read more here.
Keywords: amyloid fibrillation; conformational phase; heparin; fibrillation ... See more keywords
Characterization of a peptide containing the major heparin binding domain of human hepatic lipase
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Peptide Science"
DOI: 10.1002/psc.3123
Abstract: Human hepatic lipase (hHL) is a cell surface associated enzyme that hydrolyzes triacylglycerols and phospholipids within circulating lipoproteins. We hypothesized that an amino acid sequence mimicking the major heparin binding domain (HBD) of hHL will… read more here.
Keywords: heparin; peptide; hhl; human hepatic ... See more keywords
A Synthetic Protocell-Based Heparin Scavenger.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201790
Abstract: Heparin is a commonly applied blood anticoagulant agent in clinical use. After treatment, excess heparin needs to be removed to circumvent side effects and recover the blood-clotting cascade. Most existing heparin antidotes rely on direct… read more here.
Keywords: protocell based; synthetic protocell; scavenger; based heparin ... See more keywords
Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202203751
Abstract: Despite nearly a century of clinical use as a blood thinner, heparin's rapid serum clearance and potential to induce severe bleeding events continue to urge the development of more effective controlled delivery strategies. Subcutaneous depots… read more here.
Keywords: nanogranules thrombosis; heparin peptide; peptide nanogranules; heparin ... See more keywords
Design and development of thyroxine/heparin releasing affordable cotton dressings to treat chronic wounds.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of tissue engineering and regenerative medicine"
DOI: 10.1002/term.3295
Abstract: This research on a thyroxine/heparin-based cotton wound dressing tests angiogenic and wound healing ability of thyroxine/heparin in a chick chorionic allantoic membrane bioassay and in skin wounds in healthy rats. Commercially available cotton dressings were… read more here.
Keywords: thyroxine heparin; cotton dressings; thyroxine; heparin ... See more keywords
Überbrückende Antikoagulation bei Patienten unter Vitamin-K-Antagonisten
Sign Up to like & getrecommendations! Published in 2018 at "Der Anaesthesist"
DOI: 10.1007/s00101-018-0463-0
Abstract: ZusammenfassungUnter einer oralen Antikoagulation mit Vitamin-K-Antagonisten (VKA) müssen sich etwa 30 % der Patienten innerhalb von 2 Jahren einem chirurgischen Eingriff unterziehen. Dabei stellt sich die Frage nach der Notwendigkeit und Art einer periinterventionellen Überbrückungstherapie mit Heparin.… read more here.
Keywords: heparin; vitamin antagonisten; der; mit ... See more keywords