Guiding Fibroblast Activation Using an RGD-Mutated Heparin Binding II Fragment of Fibronectin for Gingival Titanium Integration.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203307
Abstract: The formation of a biological seal around the neck of titanium (Ti) implants is critical for ensuring integration at the gingival site and for preventing bacterial colonization that may lead to periimplantitis. This process is… read more here.
Keywords: fibronectin; rgd; integration; heparin binding ... See more keywords
Effectively enhancing cytotoxic and apoptotic effects of alpha‐momorcharin by integrating a heparin‐binding peptide
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1553
Abstract: Alpha‐momorcharin (α‐MMC), a type I ribosome‐inactivating protein, has attracted a great deal of attention because of its antitumor activity. However, the cytotoxicity of α‐MMC is limited due to insufficient cellular internalization in cancer cells. To… read more here.
Keywords: alpha momorcharin; heparin binding; mmc hbp; hbp ... See more keywords
Heparin-Binding Protein Levels at Admission and Within 24 h Are Associated with Persistent Organ Failure in Acute Pancreatitis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06660-1
Abstract: Background Identification of patients at risk for persistent organ failure (POF) early in the course of acute pancreatitis (AP) is critical for early intervention. Heparin-binding protein (HBP) levels are closely related to inflammation. Therefore, we… read more here.
Keywords: acute pancreatitis; organ failure; heparin binding; hbp ... See more keywords
Prediction of heparin binding of mutated short sequences of rat thyroglobulin
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01411-5
Abstract: Binding of thyroglobulin (Tg) to heparin is involved in Tg transcytosis via megalin. Rat Tg (rTg) binds to heparin through an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues. This region is… read more here.
Keywords: heparin binding; short sequences; heparin; secondary structure ... See more keywords
Filter-entrapment enrichment pull-down assay for glycosaminoglycan structural characterization and protein interaction.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.116623
Abstract: Heparins are the most pharmaceutically important polysaccharides. These heparin-based anticoagulant/antithrombotic agents include unfractionated heparins, low molecular weight heparins (LMWHs) and ultralow molecular weight heparins (ULMWHs). Heparins exhibit their pharmacological and biological activities through interaction with… read more here.
Keywords: heparin; filter entrapment; heparin binding; interaction ... See more keywords
N-terminus of Classical swine fever virus strain TD96 glycoprotein Erns contains a potential heparin-binding domain.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2019.03.029
Abstract: Classical swine fever virus (CSFV) envelope glycoprotein Erns has been shown to bind to cell surface sulphated-heparin-like glycosaminoglycans (GAGs), which participate in cell attachment of the virus. In this study, the CSFV Erns gene was… read more here.
Keywords: fever virus; heparin binding; heparin; classical swine ... See more keywords
On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00379
Abstract: Cystic fibrosis (CF) is a disease of dysregulated salt and fluid homeostasis that results in the massive accumulation of neutrophil elastase, resulting in lung degradation and death. The current CF therapy relies on inhaled deoxyribonuclease… read more here.
Keywords: cystic fibrosis; site neutrophil; binding site; elastase ... See more keywords
Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Investigation"
DOI: 10.1038/s41374-018-0146-0
Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive and devastating chronic lung condition that has a significant global burden, both medically and financially. Currently there are no medications that can alter the course of disease.… read more here.
Keywords: patients copd; disease; pathology; heparin binding ... See more keywords
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04525-w
Abstract: Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding domains… read more here.
Keywords: wound healing; growth factors; heparin binding; laminin ... See more keywords
Estimation of a stronger heparin binding locus in fibronectin domain III14using thermodynamics and molecular dynamics
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra01773f
Abstract: Binding Thermodynamics of FHIP I and FHIP II with heparin. read more here.
Keywords: heparin; thermodynamics; stronger heparin; heparin binding ... See more keywords
Circulating levels of inflammatory parameters pentraxin-3, cyclophilin and heparin-binding epidermal growth factor-like growth factor in patients with ST-elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2019.1698058
Abstract: Abstract Inflammatory biomarkers – pentraxin-3 (PTX3), cyclophilin A (CypA) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) were examined in patients with ST-segment elevation myocardial infarction (STEMI) undergoing revascularization with primary percutaneous coronary intervention (pPCI)… read more here.
Keywords: growth factor; growth; stemi cad; heparin binding ... See more keywords