Minimum structural requirements for BMP-2-binding of heparin oligosaccharides.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.08.056
Abstract: Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury. Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan… read more here.
Keywords: structural requirements; heparin; minimum structural; bmp binding ... See more keywords
Uncovering the detailed mode of cleavage of heparinase I toward structurally defined heparin oligosaccharides.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.08.260
Abstract: For a more insightful investigation into the specificity of bacterial heparinase I, a series of structurally well-defined heparin oligosaccharides was synthesized using a highly efficient chemoenzymatic strategy. Apart from the primary cleavage site, five glycosidic… read more here.
Keywords: uncovering detailed; cleavage; defined heparin; heparin oligosaccharides ... See more keywords