Flaxseed-derived peptides ameliorate hepatic cholesterol metabolism in Sprague-Dawley rats fed a high-cholesterol and high-fat diet.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11888
Abstract: BACKGROUND Plant peptides have been reported to have cholesterol-lowering activities. Previous research has found that ≤1k Da flaxseed peptide (FP5 ) reduces cholesterol absorption and synthesis in vitro. In this research, we investigate the cholesterol-lowering… read more here.
Keywords: high cholesterol; cholesterol; hepatic cholesterol; fed high ... See more keywords
Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00952
Abstract: Isoquercetin, a monosaccharide flavonoid, was recently reported to have significant amelioration effects on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. However, the underlying mechanism of hepatic cholesterol and triglyceride improvement in mice… read more here.
Keywords: nafld mice; hepatic cholesterol; isoquercetin; cholesterol triglyceride ... See more keywords
From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01882-5
Abstract: In a study published in Cell , Hu and colleagues discovered that the signaling activity of the intestinal hormone Cholesin leads to the attenuation of hepatic cholesterol synthesis in response to intestinal absorption thereby maintaining… read more here.
Keywords: cholesterol; unknown spotlight; synthesis; hormone ... See more keywords
Dietary Cholest-4-en-3-one, a Cholesterol Metabolite of Gut Microbiota, Alleviates Hyperlipidemia, Hepatic Cholesterol Accumulation, and Hyperinsulinemia in Obese, Diabetic db/db Mice
Sign Up to like & getrecommendations! Published in 2024 at "Metabolites"
DOI: 10.3390/metabo14060321
Abstract: Previous studies have shown that dietary cholest-4-en-3-one (4-cholestenone, 4-STN) exerts anti-obesity and lipid-lowering effects in mice. However, its underlying mechanisms are not fully understood. In the present study, we evaluated whether 4-STN supplementation would protect… read more here.
Keywords: stn; accumulation; hyperlipidemia hepatic; hepatic cholesterol ... See more keywords