Age-Related Change in Hepatic Clearance Inferred from Multiple Population Pharmacokinetic Studies: Comparison with Renal Clearance and Their Associations with Organ Weight and Blood Flow
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DOI: 10.1007/s40262-021-01069-z
Abstract: This study aimed to examine the magnitude of age-related change in hepatic clearance by integrating the data of multiple drugs and to compare this with renal clearance, considering associations with age-related changes in organ weight… read more here.
Keywords: blood flow; age related; age; clearance ... See more keywords
Validation of Methods for in Vitro-in Vivo Extrapolation Using Hepatic Clearance Measurements in Isolated Perfused Fish Livers.
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DOI: 10.1021/acs.est.2c02656
Abstract: In vitro biotransformation assays using hepatocytes or liver subcellular fractions, combined with in vitro-in vivo extrapolation (IVIVE) models, have been proposed as an alternative to live fish bioconcentration studies. The uncertainty associated with IVIVE approaches… read more here.
Keywords: clearance; vitro vivo; hepatic clearance; vivo extrapolation ... See more keywords
Predicting Hepatic Clearance of Psychotropic Drugs in Isolated Perfused Fish Livers Using a Combination of Two In Vitro Assays.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c03017
Abstract: In vitro biotransformation assays with primary trout hepatocytes (RT-HEP) or liver subcellular fractions (RT-S9) have been proposed as valuable tools to help scientists and regulators better understand the toxicokinetics of chemicals. While both assays have… read more here.
Keywords: active transport; combination; isolated perfused; hepatic clearance ... See more keywords
Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization.
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DOI: 10.1021/acs.jmedchem.0c01930
Abstract: Development of new chemical entities is costly, time-consuming, and has a low success rate. Accurate prediction of pharmacokinetic properties is critical to progress compounds with favorable drug-like characteristics in lead optimization. Of particular importance is… read more here.
Keywords: successful unsuccessful; lead optimization; clearance; hepatic clearance ... See more keywords
Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis
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DOI: 10.1111/jgh.15778
Abstract: The study was undertaken in order to compare single injection indocyanine green (ICG)‐clearances with the steady‐state ICG‐clearance (ICGCl) in patients with cirrhosis in order to assess the most accurate estimate for ICG‐clearance and to relate… read more here.
Keywords: clearance; clearance derivations; indocyanine green; determination hepatic ... See more keywords
Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma
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DOI: 10.3748/wjg.v28.i38.5614
Abstract: BACKGROUND Estimation of the functional reserve of the remnant liver is important to reduce morbidity and mortality. AIM To estimate the functional reserve of the remnant liver in patients with hepatocellular carcinoma (HCC). METHODS We… read more here.
Keywords: remnant; liver; remnant liver; hepatic clearance ... See more keywords